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  • Ulven, Stine M.University of Oslo,Univ Oslo, Inst Basic Med Sci, Dept Nutr, N-0317 Oslo, Norway (author)

An isocaloric nordic diet modulates rela and tnfrsf1a gene expression in peripheral blood mononuclear cells in individuals with metabolic syndrome—a sysdiet sub-study

  • Article/chapterEnglish2019

Publisher, publication year, extent ...

  • 2019-12-03
  • MDPI AG,2019

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:f73ec833-4917-485c-abd6-2d59f51c70a1
  • https://lup.lub.lu.se/record/f73ec833-4917-485c-abd6-2d59f51c70a1URI
  • https://doi.org/10.3390/nu11122932DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:142764558URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-406064URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • A healthy dietary pattern is associated with a lower risk of metabolic syndrome (MetS) and reduced inflammation. To explore this at the molecular level, we investigated the effect of a Nordic diet (ND) on changes in the gene expression profiles of inflammatory and lipid-related genes in peripheral blood mononuclear cells (PBMCs) of individuals with MetS. We hypothesized that the intake of an ND compared to a control diet (CD) would alter the expression of inflammatory genes and genes involved in lipid metabolism. The individuals with MetS underwent an 18/24-week randomized intervention to compare a ND with a CD. Eighty-eight participants (66% women) were included in this sub-study of the larger SYSDIET study. Fasting PBMCs were collected before and after the intervention and changes in gene expression levels were measured using TaqMan Array Micro Fluidic Cards. Forty-eight pre-determined inflammatory and lipid related gene transcripts were analyzed. The expression level of the gene tumor necrosis factor (TNF) receptor superfamily member 1A (TNFRSF1A) was down-regulated (p = 0.004), whereas the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) subunit, RELA proto-oncogene, was up-regulated (p = 0.016) in the ND group compared to the CD group. In conclusion, intake of an ND in individuals with the MetS may affect immune function.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Holven, Kirsten B.University of Oslo,Oslo university hospital,Univ Oslo, Inst Basic Med Sci, Dept Nutr, N-0317 Oslo, Norway;Oslo Univ Hosp, Dept Endocrinol Morbid Obes & Prevent Med, Natl Advisory Unit Familial Hypercholesterlemia, N-0424 Oslo, Norway (author)
  • Rundblad, AmandaUniversity of Oslo,Univ Oslo, Inst Basic Med Sci, Dept Nutr, N-0317 Oslo, Norway (author)
  • Myhrstad, Mari C.W.Oslo Metropolitan University,OsloMet Oslo Metropolitan Univ, Dept Nursing & Hlth Promot, Fac Hlth Sci, N-0130 Oslo, Norway,Univ Eastern Finland, Inst Biomed, Kuopio 70211, Finland (author)
  • Leder, LenaMills AS, Sofienberggt 19, N-0558 Oslo, Norway (author)
  • Dahlman, IngridKarolinska Institutet,Karolinska Institute,Karolinska Inst, Dept Med H7, S-17176 Stockholm, Sweden (author)
  • de Mello, Vanessa D.University of Eastern Finland,Univ Eastern Finland, Inst Publ Hlth & Clin Nutr, Sch Med, Kuopio 70211, Finland (author)
  • Schwab, UrsulaKuopio University Hospital,University of Eastern Finland,Univ Eastern Finland, Inst Publ Hlth & Clin Nutr, Sch Med, Kuopio 70211, Finland;Kuopio Univ Hosp, Dept Med Endocrinol & Clin Nutr, Kuopio 70029, Finland (author)
  • Carlberg, CarstenUniversity of Eastern Finland (author)
  • Pihlajamäki, JussiKuopio University Hospital,University of Eastern Finland,Univ Eastern Finland, Inst Publ Hlth & Clin Nutr, Sch Med, Kuopio 70211, Finland;Kuopio Univ Hosp, Dept Med Endocrinol & Clin Nutr, Kuopio 70029, Finland (author)
  • Hermansen, KjeldAarhus University Hospital,Aarhus Univ, Aarhus Univ Hosp, Dept Endocrinol & Internal Med, Dept Clin Med, DK-8200 Aarhus, Denmark (author)
  • Dragsted, Lars O.University of Copenhagen,Univ Copenhagen, Dept Nutr Exercise & Sports, Fac Sci, DK-2200 Copenhagen, Denmark (author)
  • Gunnarsdottir, IngibjörgNational University Hospital of Iceland,Univ Iceland, Unit Nutr Res, IS-101 Reykjavik, Iceland;Landspitali Natl Univ Hosp Iceland, IS-101 Reykjavik, Iceland (author)
  • Cloetens, LieselotteLund University,Lunds universitet,Tillämpad biokemi,Centrum för tillämpade biovetenskaper,Kemiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Pure and Applied Biochemistry,Center for Applied Life Sciences,Department of Chemistry,Departments at LTH,Faculty of Engineering, LTH,Lund Univ, Biomed Nutr Pure & Appl Biochem, S-22100 Lund, Sweden(Swepub:lu)tbio-lce (author)
  • Åkesson, BjörnLund University,Lunds universitet,Tillämpad biokemi,Centrum för tillämpade biovetenskaper,Kemiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Pure and Applied Biochemistry,Center for Applied Life Sciences,Department of Chemistry,Departments at LTH,Faculty of Engineering, LTH,Skåne University Hospital,Lund Univ, Biomed Nutr Pure & Appl Biochem, S-22100 Lund, Sweden;Skane Univ Hosp, Dept Clin Nutr, S-22100 Lund, Sweden(Swepub:lu)kc-bak (author)
  • Rosqvist, Fredrik,1985-Uppsala universitet,Uppsala University,Klinisk nutrition och metabolism(Swepub:uu)frero353 (author)
  • Hukkanen, JanneOulu University Hospital,University of Oulu,Univ Oulu, Dept Internal Med, Inst Clin Med, Med Res Ctr,Oulu Univ Hosp, SF-90220 Oulu, Finland;Univ Oulu, Bioctr Oulu, Oulu Univ Hosp, Med Res Ctr, SF-90220 Oulu, Finland (author)
  • Herzig, Karl HeinzPoznan University of Medical Sciences,Oulu University Hospital,Univ Oulu, Fac Med, Med Res Ctr, Inst Biomed,Bioctr Oulu, SF-90220 Oulu, Finland;Oulu Univ Hosp, Oulu 90220, Finland;Poznan Univ Med Sci, Dept Gastroenterol & Metab, PL-60572 Poznan, Poland (author)
  • Savolainen, Markku J.University of Oulu,Oulu University Hospital,Univ Oulu, Dept Internal Med, Inst Clin Med, Med Res Ctr,Oulu Univ Hosp, SF-90220 Oulu, Finland;Univ Oulu, Bioctr Oulu, Oulu Univ Hosp, Med Res Ctr, SF-90220 Oulu, Finland (author)
  • Risérus, Ulf,1967-Uppsala universitet,Uppsala University,Klinisk nutrition och metabolism(Swepub:uu)ulfriser (author)
  • Thorsdottir, IngaNational University Hospital of Iceland,Univ Iceland, Unit Nutr Res, IS-101 Reykjavik, Iceland;Landspitali Natl Univ Hosp Iceland, IS-101 Reykjavik, Iceland (author)
  • Poutanen, Kaisa S.VTT Technical Research Center of Finland, Espoo,University of Eastern Finland,Univ Eastern Finland, Inst Publ Hlth & Clin Nutr, Sch Med, Kuopio 70211, Finland;VTT Tech Res Ctr Finland, Espoo 021100, Finland (author)
  • Arner, PeterKarolinska Institutet,Karolinska Institute,Karolinska Inst, Dept Med H7, S-17176 Stockholm, Sweden (author)
  • Uusitupa, MattiUniversity of Eastern Finland,Univ Eastern Finland, Inst Publ Hlth & Clin Nutr, Sch Med, Kuopio 70211, Finland (author)
  • Kolehmainen, MarjukkaUniversity of Eastern Finland,Univ Eastern Finland, Inst Publ Hlth & Clin Nutr, Sch Med, Kuopio 70211, Finland (author)
  • University of OsloUniv Oslo, Inst Basic Med Sci, Dept Nutr, N-0317 Oslo, Norway (creator_code:org_t)

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  • In:Nutrients: MDPI AG11:122072-6643

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