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Plasma protein biom...
Plasma protein biomarkers predict the development of persistent autoantibodies and type 1 diabetes 6 months prior to the onset of autoimmunity
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- Nakayasu, Ernesto S (author)
- Pacific Northwest National Laboratory
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- Bramer, Lisa M (author)
- Pacific Northwest National Laboratory
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- Ansong, Charles (author)
- Pacific Northwest National Laboratory
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- Schepmoes, Athena A (author)
- Pacific Northwest National Laboratory
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- Fillmore, Thomas L (author)
- Pacific Northwest National Laboratory
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- Gritsenko, Marina A (author)
- Pacific Northwest National Laboratory
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- Clauss, Therese R (author)
- Pacific Northwest National Laboratory
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- Gao, Yuqian (author)
- Pacific Northwest National Laboratory
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- Piehowski, Paul D (author)
- Pacific Northwest National Laboratory
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- Stanfill, Bryan A (author)
- Pacific Northwest National Laboratory
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- Engel, Dave W (author)
- Pacific Northwest National Laboratory
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- Orton, Daniel J (author)
- Pacific Northwest National Laboratory
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- Moore, Ronald J (author)
- Pacific Northwest National Laboratory
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- Qian, Wei-Jun (author)
- Pacific Northwest National Laboratory
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- Sechi, Salvatore (author)
- National Institutes of Health, United States
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- Frohnert, Brigitte I (author)
- University of Colorado-Denver
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- Toppari, Jorma (author)
- Turku University Hospital,University of Turku
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- Ziegler, Anette-G (author)
- Technical University of Munich,Helmholtz Zentrum München
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- Lernmark, Åke (author)
- Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups,Skåne University Hospital
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- Hagopian, William (author)
- Pacific Northwest Research Institute
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- Akolkar, Beena (author)
- National Institutes of Health, United States
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- Smith, Richard D (author)
- Pacific Northwest National Laboratory
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- Rewers, Marian J (author)
- University of Colorado-Denver
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- Webb-Robertson, Bobbie-Jo M (author)
- Pacific Northwest National Laboratory
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- Metz, Thomas O (author)
- Pacific Northwest National Laboratory
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(creator_code:org_t)
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- 2023
- 2023
- English.
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In: Cell Reports Medicine. - 2666-3791. ; 4:7
- Related links:
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http://dx.doi.org/10... (free)
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
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- Type 1 diabetes (T1D) results from autoimmune destruction of β cells. Insufficient availability of biomarkers represents a significant gap in understanding the disease cause and progression. We conduct blinded, two-phase case-control plasma proteomics on the TEDDY study to identify biomarkers predictive of T1D development. Untargeted proteomics of 2,252 samples from 184 individuals identify 376 regulated proteins, showing alteration of complement, inflammatory signaling, and metabolic proteins even prior to autoimmunity onset. Extracellular matrix and antigen presentation proteins are differentially regulated in individuals who progress to T1D vs. those that remain in autoimmunity. Targeted proteomics measurements of 167 proteins in 6,426 samples from 990 individuals validate 83 biomarkers. A machine learning analysis predicts if individuals would remain in autoimmunity or develop T1D 6 months before autoantibody appearance, with areas under receiver operating characteristic curves of 0.871 and 0.918, respectively. Our study identifies and validates biomarkers, highlighting pathways affected during T1D development.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
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- By the author/editor
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Nakayasu, Ernest ...
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Bramer, Lisa M
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Ansong, Charles
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Schepmoes, Athen ...
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Fillmore, Thomas ...
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Gritsenko, Marin ...
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show more...
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Clauss, Therese ...
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Gao, Yuqian
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Piehowski, Paul ...
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Stanfill, Bryan ...
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Engel, Dave W
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Orton, Daniel J
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Moore, Ronald J
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Qian, Wei-Jun
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Sechi, Salvatore
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Frohnert, Brigit ...
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Toppari, Jorma
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Ziegler, Anette- ...
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Lernmark, Åke
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Hagopian, Willia ...
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Akolkar, Beena
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Smith, Richard D
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Rewers, Marian J
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Webb-Robertson, ...
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Metz, Thomas O
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Cell and Molecul ...
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Cell Reports Med ...
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Lund University