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Risk prediction for...
Risk prediction for renal cell Carcinoma : Results from the European Prospective Investigation into Cancer and nutrition (EPIC) prospective cohort study
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- Singleton, Rosie K. (author)
- School of Public Health, Imperial College London, London, United Kingdom
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- Heath, Alicia K. (author)
- School of Public Health, Imperial College London, London, United Kingdom
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- Clasen, Joanna L. (author)
- School of Public Health, Imperial College London, London, United Kingdom
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- Scelo, Ghislaine (author)
- Cancer Epidemiology Unit, University of Turin, Turin, Italy
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- Johansson, Mattias (author)
- International Agency for Research on Cancer, World Health Organization,International Agency for Research on Cancer, Lyon, France
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- Le Calvez-Kelm, Florence (author)
- International Agency for Research on Cancer, World Health Organization,International Agency for Research on Cancer, Lyon, France
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- Weiderpass, Elisabete (author)
- International Agency for Research on Cancer, World Health Organization,International Agency for Research on Cancer, Lyon, France
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- Liedberg, Fredrik (author)
- Lund University,Lunds universitet,Urologi - blåscancer, Malmö,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Urology - urothelial cancer, Malmö,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Institution of Translational Medicine, Lund University, Malmo, Sweden
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- Ljungberg, Börje, Professor, 1949- (author)
- Umeå universitet,Umeå University,Urologi och andrologi
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- Harbs, Justin (author)
- Umeå universitet,Umeå University,Diagnostisk radiologi
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- Olsen, Anja (author)
- Danish Cancer Society Research Center, Copenhagen, Denmark; Department of Public Health, University of Århus, Århus, Denmark,Aarhus University
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- Tjønneland, Anne (author)
- Danish Cancer Society Research Center, Copenhagen, Denmark; Department of Public Health, University of Copenhagen, Copenhagen, Denmark,Danish Cancer Society
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- Dahm, Christina C. (author)
- Department of Public Health, Aarhus University, Denmark
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- Kaaks, Rudolf (author)
- Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
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- Fortner, Renee T. (author)
- Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
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- Panico, Salvatore (author)
- Department of Clinical and Surgical Medicine, Federico II University, Naples, Italy
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- Tagliabue, Giovanna (author)
- Lombardy Cancer Registry Unit, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy
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- Masala, Giovanna (author)
- Cancer Risk Factors and Life-Style Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network–ISPRO, Florence, Italy
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- Tumino, Rosario (author)
- Cancer Registry and Histopathology Department, Provincial Health Authority (ASP 7), Ragusa, Italy
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- Ricceri, Fulvio (author)
- Azienda Sanitaria Locale Torino 3,Department of Clinical and Biological Sciences, University of Turin, Orbassano (TO), Italy; Unit of Epidemiology Regional Health Service ASL TO3, Grugliasco (TO), Italy
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- Gram, Inger T. (author)
- UiT The Arctic University of Norway, Tromsø,Faculty of Health Sciences, Department of Community Medicine, University of Tromsø, Arctic University of Norway, Tromsø, Norway
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- Santiuste, Carmen (author)
- Department of Epidemiology, Murcia Regional Health Council, IMIB-Arrixaca, Murcia, Spain; CIBER Epidemiología y Salud Publica (CIBERESP), Spain,CIBER Epidemiology and Public Health (CIBERESP)
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- Bonet, Catalina (author)
- Unit of Nutrition, Environment, and Cancer, Catalan Institute of Oncology, Barcelona, Spain
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- Rodriguez-Barranco, Miguel (author)
- Andalusian School Of Public Health (EASP),CIBER Epidemiology and Public Health (CIBERESP),Escuela Andaluza de Salud Publica (EASP), Granada, Madrid, Spain; Instituto de Investigacion Biosanitaria ibs.GRANADA, Granada, Spain; Centro de Investigacion Biomedicaen Red de Epidemiología y Salud Publica (CIBERESP), Madrid, Spain
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- Schulze, Mattias B. (author)
- Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke (DifE), Potsdam, Germany; Institute of Nutrition Science, University of Potsdam, Nuthetal, Germany,University of Potsdam
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- Bergmann, Manuela M. (author)
- Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbrucke (DifE), Potsdam, Germany
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- Travis, Ruth C. (author)
- Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom
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- Tzoulaki, Ioanna (author)
- School of Public Health, Imperial College London, London, United Kingdom; MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London, United Kingdom; University of Ioannina Medical School, Ioannina, Greece,University of Ioannina
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- Riboli, Elio (author)
- School of Public Health, Imperial College London, London, United Kingdom
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- Muller, David C. (author)
- School of Public Health, Imperial College London, London, United Kingdom
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(creator_code:org_t)
- AACR, 2021
- 2021
- English 6 s.
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In: Cancer Epidemiology Biomarkers and Prevention. - : AACR. - 1055-9965 .- 1538-7755. ; 30:3, s. 507-512
- Related links:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Subject headings
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- Background: Early detection of renal cell carcinoma (RCC) has the potential to improve disease outcomes. No screening program for sporadic RCC is in place. Given relatively low incidence, screening would need to focus on people at high risk of clinically meaningful disease so as to limit overdiagnosis and screen-detected false positives. Methods: Among 192,172 participants from the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort (including 588 incident RCC cases), we evaluated a published RCC risk prediction model (including age, sex, BMI, and smoking status) in terms of discrimination (C-statistic) and calibration (observed probability as a function of predicted probability). We used a flexible parametric survival model to develop an expanded model including age, sex, BMI, and smoking status, with the addition of self-reported history of hypertension and measured blood pressure. Results: The previously published model yielded well-calibrated probabilities and good discrimination (C-statistic [95% CI]: 0.699 [0.679–0.721]). Our model had slightly improved discrimination (0.714 [0.694–0.735], bootstrap optimism-corrected C-statistic: 0.709). Despite this good performance, predicted risk was low for the vast majority of participants, with 70% of participants having 10-year risk less than 0.0025. Conclusions: Although the models performed well for the prediction of incident RCC, they are currently insufficiently powerful to identify individuals at substantial risk of RCC in a general population. Impact: Despite the promising performance of the EPIC RCC risk prediction model, further development of the model, possibly including biomarkers of risk, is required to enable risk stratification of RCC.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
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- By the author/editor
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Singleton, Rosie ...
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Heath, Alicia K.
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Clasen, Joanna L ...
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Scelo, Ghislaine
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Johansson, Matti ...
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Le Calvez-Kelm, ...
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show more...
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Weiderpass, Elis ...
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Liedberg, Fredri ...
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Ljungberg, Börje ...
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Harbs, Justin
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Olsen, Anja
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Tjønneland, Anne
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Dahm, Christina ...
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Kaaks, Rudolf
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Fortner, Renee T ...
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Panico, Salvator ...
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Tagliabue, Giova ...
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Masala, Giovanna
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Tumino, Rosario
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Ricceri, Fulvio
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Gram, Inger T.
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Santiuste, Carme ...
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Bonet, Catalina
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Rodriguez-Barran ...
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Schulze, Mattias ...
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Bergmann, Manuel ...
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Travis, Ruth C.
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Tzoulaki, Ioanna
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Riboli, Elio
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Muller, David C.
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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MEDICAL AND HEAL ...
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and Health Sciences
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MEDICAL AND HEAL ...
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Cancer Epidemiol ...
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Lund University
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Umeå University