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Sökning: onr:"swepub:oai:lup.lub.lu.se:f82ab630-2a53-4b2e-bfcb-b11720cde6cc" > Predictive value of...

  • Olah, CsillaUniversity of Duisburg-Essen (författare)

Predictive value of molecular subtypes and APOBEC3G for adjuvant chemotherapy in urothelial bladder cancer

  • Artikel/kapitelEngelska2023

Förlag, utgivningsår, omfång ...

  • 2022-10-07
  • Wiley,2023

Nummerbeteckningar

  • LIBRIS-ID:oai:lup.lub.lu.se:f82ab630-2a53-4b2e-bfcb-b11720cde6cc
  • https://lup.lub.lu.se/record/f82ab630-2a53-4b2e-bfcb-b11720cde6ccURI
  • https://doi.org/10.1002/cam4.5324DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:art swepub-publicationtype
  • Ämneskategori:ref swepub-contenttype

Anmärkningar

  • Objective: Although targeted approaches have become available in second- and third-line settings, platinum-based chemotherapy remains the standard first-line treatment for advanced muscle-invasive bladder cancer (MIBC). Therefore, the prediction of platinum resistance is of utmost clinical importance. Methods: In this study, we established a routine compatible method for the molecular classification of MIBC samples according to various classification systems and applied this method to evaluate the impact of subtypes on survival after adjuvant chemotherapy. This retrospective study included 191 patients with advanced MIBC (pT≥3 or pN+) who underwent radical cystectomy, with or without adjuvant chemotherapy. A 48-gene panel and classifier rule set were established to determine molecular subtypes according to TCGA, MDA, LundTax, and Consensus classifications. Additionally, 12 single platinum-predictive candidate genes were assessed. The results were correlated with patients' clinicopathological and follow-up data and were validated using independent data sets. Results: Our final evaluation of 159 patients demonstrated better survival in the luminal groups for those who received chemotherapy compared with those who did not. In contrast, no such differences were observed in basal subtypes. The use of chemotherapy was associated with better survival in patients with high APOBEC3G expression (p < 0.002). This association was confirmed using an independent data set of patients who received neoadjuvant platinum therapy. Conclusions: The proposed method robustly replicates the most commonly used transcriptome-based subtype classifications from paraffin-embedded tissue samples. The luminal, but not basal, molecular subtypes had the greatest benefit from adjuvant platinum therapy. We identified and validated APOBEC3G as a novel predictive marker for platinum-treated patients.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Reis, HenningUniversity Hospital Frankfurt (författare)
  • Hoffmann, Michèle J.University Hospital of Düsseldorf (författare)
  • Mairinger, FabianUniversity of Duisburg-Essen (författare)
  • Ting, SaskiaUniversity of Duisburg-Essen (författare)
  • Hadaschik, BorisUniversity of Duisburg-Essen (författare)
  • Krafft, UlrichUniversity of Duisburg-Essen (författare)
  • Grünwald, ViktorUniversity of Duisburg-Essen (författare)
  • Nyirady, PeterSemmelweis University (författare)
  • Varadi, MelindaSemmelweis University (författare)
  • Győrffy, BalázsSemmelweis University (författare)
  • Kiss, AndrasSemmelweis University (författare)
  • Szekely, EszterSemmelweis University (författare)
  • Sjödahl, GottfridLund University,Lunds universitet,Urologi - blåscancer, Malmö,Forskargrupper vid Lunds universitet,Genomiska analyser av urinblåscancer,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Urinblåsecancer,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Urology - urothelial cancer, Malmö,Lund University Research Groups,Urothelial Cancer Genomics,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Urothelial cancer,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)med-gsj (författare)
  • Szarvas, TiborUniversity of Duisburg-Essen (författare)
  • University of Duisburg-EssenUniversity Hospital Frankfurt (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Cancer Medicine: Wiley12:5, s. 5222-52322045-7634

Internetlänk

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