WFRF:(Hassan Amin S)
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- Hassan, Amin S.Lund University,Lunds universitet,Klinisk virologi, Malmö,Forskargrupper vid Lunds universitet,Clinical Virology, Malmö,Lund University Research Groups,Centre for Geographic Medicine Research, Kilifi (author)
Defining HIV-1 transmission clusters based on sequence data : a systematic review and perspectives
- Article/chapterEnglish2017
Publisher, publication year, extent ...
- 2017
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- LIBRIS-ID:oai:lup.lub.lu.se:f8635823-82a0-4f37-bf10-dcc2e28f635b
- https://lup.lub.lu.se/record/f8635823-82a0-4f37-bf10-dcc2e28f635bURI
- https://doi.org/10.1097/QAD.0000000000001470DOI
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- Language:English
- Summary in:English
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- SwePubSwePub
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- Understanding HIV-1 transmission dynamics is relevant to both screening and intervention strategies of HIV-1 infection. Commonly, HIV-1 transmission chains are determined based on sequence similarity assessed either directly from a sequence alignment or by inferring a phylogenetic tree. This review is aimed at both nonexperts interested in understanding and interpreting studies of HIV-1 transmission, and experts interested in finding the most appropriate cluster definition for a specific dataset and research question. We start by introducing the concepts and methodologies of how HIV-1 transmission clusters usually have been defined. We then present the results of a systematic review of 105 HIV-1 molecular epidemiology studies summarising the most popular methods and definitions in the literature. Finally, we offer our perspectives on how HIV-1 transmission clusters can be defined and provide some guidance based on examples from real life datasets.
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- Pybus, Oliver GUniversity of Oxford (author)
- Sanders, Eduard J.Centre for Geographic Medicine Research, Kilifi,University of Oxford (author)
- Albert, JanKarolinska Institute (author)
- Esbjörnsson, JoakimKarolinska Institute,University of Oxford(Swepub:lu)med-jes (author)
- Klinisk virologi, MalmöForskargrupper vid Lunds universitet (creator_code:org_t)
Related titles
- In:AIDS31:9, s. 1211-12220269-9370
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