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  • Lindgren Belal, SarahLund University,Lunds universitet,Institutionen för translationell medicin,Medicinska fakulteten,Department of Translational Medicine,Faculty of Medicine (author)

3D skeletal uptake of F-18 sodium fluoride in PET/CT images is associated with overall survival in patients with prostate cancer

  • Article/chapterEnglish2017

Publisher, publication year, extent ...

  • 2017-02-16
  • Springer Science and Business Media LLC,2017
  • electronicrdacarrier

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  • LIBRIS-ID:oai:research.chalmers.se:54d570a9-6932-4620-ad6c-dc507f397670
  • https://doi.org/10.1186/s13550-017-0264-5DOI
  • https://research.chalmers.se/publication/248751URI
  • https://lup.lub.lu.se/record/b4d582dd-e91e-435e-ae12-3e3866d37e7bURI

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  • Language:English
  • Summary in:English

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  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

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  • Background: Sodium fluoride (NaF) positron emission tomography combined with computer tomography (PET/CT) has shown to be more sensitive than the whole-body bone scan in the detection of skeletal uptake due to metastases in prostate cancer. We aimed to calculate a 3D index for NaF PET/CT and investigate its correlation to the bone scan index (BSI) and overall survival (OS) in a group of patients with prostate cancer. Methods: NaF PET/CT and bone scans were studied in 48 patients with prostate cancer. Automated segmentation of the thoracic and lumbar spines, sacrum, pelvis, ribs, scapulae, clavicles, and sternum were made in the CT images. Hotspots in the PET images were selected using both a manual and an automated method. The volume of each hotspot localized in the skeleton in the corresponding CT image was calculated. Two PET/CT indices, based on manual (manual PET index) and automatic segmenting using a threshold of SUV 15 (automated PET15 index), were calculated by dividing the sum of all hotspot volumes with the volume of all segmented bones. BSI values were obtained using a software for automated calculations. Results: BSI, manual PET index, and automated PET15 index were all significantly associated with OS and concordance indices were 0.68, 0.69, and 0.70, respectively. The median BSI was 0.39 and patients with a BSI > 0.39 had a significantly shorter median survival time than patients with a BSI 0.53 had a significantly shorter median survival time than patients with a manual PET index 0.11 had a significantly shorter median survival time than patients with an automated PET15 index

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  • Sadik, M.Sahlgrenska universitetssjukhuset,Sahlgrenska University Hospital (author)
  • Kaboteh, R.Sahlgrenska universitetssjukhuset,Sahlgrenska University Hospital (author)
  • Hasani, N.Sahlgrenska universitetssjukhuset,Sahlgrenska University Hospital (author)
  • Enqvist, Olof,1981Chalmers University of Technology(Swepub:cth)enolof (author)
  • Svarm, L.Eigenvision AB (author)
  • Kahl, Fredrik,1972Chalmers University of Technology(Swepub:cth)kahlf (author)
  • Simonsen, J.Odense University Hospital (author)
  • Poulsen, M. H.Odense University Hospital (author)
  • Ohlsson, MattiasLund University,Lunds universitet,Institutionen för astronomi och teoretisk fysik - Genomgår omorganisation,Naturvetenskapliga fakulteten,Department of Astronomy and Theoretical Physics - Undergoing reorganization,Faculty of Science(Swepub:lu)thep-moh (author)
  • Hoilund-Carlsen, P. F.Odense University Hospital (author)
  • Edenbrandt, LarsSahlgrenska universitetssjukhuset,Sahlgrenska University Hospital(Swepub:lu)klfy-led (author)
  • Trägårdh, ElinLund University,Lunds universitet,Institutionen för translationell medicin,Medicinska fakulteten,Department of Translational Medicine,Faculty of Medicine(Swepub:lu)klin-etr (author)
  • Institutionen för translationell medicinMedicinska fakulteten (creator_code:org_t)

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  • In:EJNMMI Research: Springer Science and Business Media LLC7:12191-219X

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