Milk : A postnatal imprinting system stabilizing FoxP3 expression and regulatory T cell differentiation

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Melnik, Bodo C.University of Osnabrück (author)

Milk : A postnatal imprinting system stabilizing FoxP3 expression and regulatory T cell differentiation

Article/chapterEnglish2016

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2016-05-12
Wiley,2016

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LIBRIS-ID:oai:lup.lub.lu.se:f8fd46b9-96de-46a6-a315-25b019f37fec
https://lup.lub.lu.se/record/f8fd46b9-96de-46a6-a315-25b019f37fecURI
https://doi.org/10.1186/s13601-016-0108-9DOI

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Language:English
Summary in:English

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SwePubSwePub

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Subject category:for swepub-publicationtype
Subject category:ref swepub-contenttype

Notes

Background: Breastfeeding has protective effects for the development of allergies and atopy. Recent evidence underlines that consumption of unboiled farm milk in early life is a key factor preventing the development of atopic diseases. Farm milk intake has been associated with increased demethylation of FOXP3 and increased numbers of regulatory T cells (Tregs). Thus, the questions arose which components of farm milk control the differentiation and function of Tregs, critical T cell subsets that promote tolerance induction and inhibit the development of allergy and autoimmunity. Findings: Based on translational research we identified at least six major signalling pathways that could explain milk's biological role controlling stable FoxP3 expression and Treg differentiation: (1) via maintaining appropriate magnitudes of Akt-mTORC1 signalling, (2) via transfer of milk fat-derived long-chain ω-3 fatty acids, (3) via transfer of milk-derived exosomal microRNAs that apparently decrease FOXP3 promoter methylation, (4) via transfer of exosomal transforming growth factor-β, which induces SMAD2/SMAD3-dependent FoxP3 expression, (5) via milk-derived Bifidobacterium and Lactobacillus species that induce interleukin-10 (IL-10)-mediated differentiation of Tregs, and (6) via milk-derived oligosaccharides that serve as selected nutrients for the growth of bifidobacteria in the intestine of the new born infant. Conclusion: Accumulating evidence underlines that milk is a complex signalling and epigenetic imprinting network that promotes stable FoxP3 expression and long-lasting Treg differentiation, crucial postnatal events preventing atopic and autoimmune diseases.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Reumatologi och inflammation hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Rheumatology and Autoimmunity hsv//eng
Epigenetic
Exosome
FoxO1
FoxP3
MicroRNA
Milk
mTORC1
Probiotics
TGF-β
Treg

Added entries (persons, corporate bodies, meetings, titles ...)

John, Swen MalteUniversity of Osnabrück (author)
Carrera-Bastos, PedroLund University,Lunds universitet,Allmänmedicin, kardiovaskulär epidemiologi och levnadsvanor,Forskargrupper vid Lunds universitet,Family Medicine, Cardiovascular Epidemiology and Lifestyle,Lund University Research Groups(Swepub:lu)med-pc_ (author)
Schmitz, GerdUniversity Hospital Regensburg (author)
University of OsnabrückAllmänmedicin, kardiovaskulär epidemiologi och levnadsvanor (creator_code:org_t)

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In:Clinical and Translational Allergy: Wiley6:12045-7022

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