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Estimated salt inta...
Estimated salt intake and risk of atrial fibrillation in a prospective community-based cohort
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- Wuopio, Jonas (författare)
- Karolinska Institutet,Uppsala universitet,Centrum för klinisk forskning Dalarna,Mora Cty Hosp, Dept Med, Mora, Sweden.
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- Orho-Melander, M. (författare)
- Lund University,Lunds universitet,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,Diabetes - Cardiovascular Disease,Lund University Research Groups,Lund Univ, Genet Epidemiol, Dept Clin Sci Diabet & Cardiovasc Dis, Malmö, Sweden.
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- Ärnlöv, Johan, 1970- (författare)
- Högskolan Dalarna,Karolinska Institute,Dalarna University College,Medicinsk vetenskap,Karolinska Institutet,Dalarna Univ, Sch Hlth & Social Studies, Falun, Sweden.;Karolinska Inst, Family Med & Primary Care Unit, Dept Neurobiol Care Sci & Soc NVS, Huddinge, Sweden.
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- Nowak, C. (författare)
- Karolinska Institutet,Karolinska Institute,Karolinska Inst, Family Med & Primary Care Unit, Dept Neurobiol Care Sci & Soc NVS, Huddinge, Sweden.
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(creator_code:org_t)
- 2020-11-19
- 2021
- Engelska 9 s.
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Ingår i: Journal of Internal Medicine. - : Wiley. - 0954-6820 .- 1365-2796. ; 289:5, s. 700-708
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Abstract
Ämnesord
Stäng
- Introduction: Hypertension predisposes to atrial fibrillation (AF) – a major risk factor for ischaemic stroke. Since a high dietary salt consumption is associated with hypertension, we investigated the association between urinary sodium excretion as a marker for dietary sodium intake and risk of new-onset AF in community-dwelling adults. Method: The UK Biobank includes 40- to 69-year-old British residents recruited 2006–2010. Participants were divided into sex-specific quintiles according to 24-hour sodium excretion estimated based on spot samples with the Kawasaki equation. We excluded participants with AF at baseline. Cox regression adjusted for cardiovascular risk factors was used to assess associations with risk of AF, using the third quintile as reference. Results: A total of 257 545 women and 215 535 men were included. During up to 10 years' follow-up, 2221 women and 3751 men were diagnosed with AF. There was a tendency for an increased risk of AF in the lowest and highest quintiles of estimated daily salt intake in both women and men. In the fully adjusted model, significant associations were seen amongst men in the lowest and highest quintiles of sodium excretion (hazard ratio, HRQv1, 1.20; 95% CI, 1.08–1.32, P < 0.001, and HRQv5 1.15, 95% CI, 1.03–1.27, P = 0.011). Conclusion: We found evidence for a U-shaped association between estimated daily salt intake and AF risk amongst men. A suggestive J-shaped association in women was not statistically confirmed, but analyses were likely underpowered. Our results suggest that above a certain physiological minimum level progressively higher salt intake is associated with increasing risk of AF.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Nyckelord
- atrial fibrillation
- blood pressure
- dietary salt
- hypertension
- Kawasaki formulae
- sodium excretion
- Kawasaki formulae
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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