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  • Obura, M.Amsterdam UMC - Vrije Universiteit Amsterdam (author)

Clinical profiles of post-load glucose subgroups and their association with glycaemic traits over time : An IMI-DIRECT study

  • Article/chapterEnglish2021

Publisher, publication year, extent ...

  • 2020-11-03
  • Wiley,2021

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:f94ba062-1244-4b13-b412-e2d88439d9ce
  • https://lup.lub.lu.se/record/f94ba062-1244-4b13-b412-e2d88439d9ceURI
  • https://doi.org/10.1111/dme.14428DOI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Aim: To examine the hypothesis that, based on their glucose curves during a seven-point oral glucose tolerance test, people at elevated type 2 diabetes risk can be divided into subgroups with different clinical profiles at baseline and different degrees of subsequent glycaemic deterioration. Methods: We included 2126 participants at elevated type 2 diabetes risk from the Diabetes Research on Patient Stratification (IMI-DIRECT) study. Latent class trajectory analysis was used to identify subgroups from a seven-point oral glucose tolerance test at baseline and follow-up. Linear models quantified the associations between the subgroups with glycaemic traits at baseline and 18 months. Results: At baseline, we identified four glucose curve subgroups, labelled in order of increasing peak levels as 1–4. Participants in Subgroups 2–4, were more likely to have higher insulin resistance (homeostatic model assessment) and a lower Matsuda index, than those in Subgroup 1. Overall, participants in Subgroups 3 and 4, had higher glycaemic trait values, with the exception of the Matsuda and insulinogenic indices. At 18 months, change in homeostatic model assessment of insulin resistance was higher in Subgroup 4 (β = 0.36, 95% CI 0.13–0.58), Subgroup 3 (β = 0.30; 95% CI 0.10–0.50) and Subgroup 2 (β = 0.18; 95% CI 0.04–0.32), compared to Subgroup 1. The same was observed for C-peptide and insulin. Five subgroups were identified at follow-up, and the majority of participants remained in the same subgroup or progressed to higher peak subgroups after 18 months. Conclusions: Using data from a frequently sampled oral glucose tolerance test, glucose curve patterns associated with different clinical characteristics and different rates of subsequent glycaemic deterioration can be identified.

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Added entries (persons, corporate bodies, meetings, titles ...)

  • Beulens, J. W.J.Amsterdam UMC - Vrije Universiteit Amsterdam,University Medical Center Utrecht (author)
  • Slieker, R.Amsterdam UMC - Vrije Universiteit Amsterdam,Leiden University Medical Centre (author)
  • Koopman, A. D.M.Amsterdam UMC - Vrije Universiteit Amsterdam (author)
  • Hoekstra, T.Vrije Universiteit Amsterdam,Amsterdam UMC - Vrije Universiteit Amsterdam (author)
  • Nijpels, G.Amsterdam UMC - Vrije Universiteit Amsterdam (author)
  • Elders, P.Amsterdam UMC - Vrije Universiteit Amsterdam (author)
  • Dekker, J. M.Amsterdam UMC - Vrije Universiteit Amsterdam (author)
  • Koivula, R. W.Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups,University of Oxford(Swepub:lu)med-rkl (author)
  • Kurbasic, A.Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups(Swepub:lu)mats-aku (author)
  • Laakso, M.University of Eastern Finland,Kuopio University Hospital (author)
  • Hansen, T. H.Slagelse Hospital,University of Copenhagen (author)
  • Ridderstråle, M.University of Copenhagen(Swepub:lu)endo-mri (author)
  • Hansen, T.University of Copenhagen,University of Southern Denmark (author)
  • Pavo, I.Eli Lilly Regional Operations G.m.b.H. (author)
  • Forgie, I.University of Dundee (author)
  • Jablonka, B.Sanofi-Aventis Deutschland GmbH (author)
  • Ruetten, H.Sanofi-Aventis Deutschland GmbH (author)
  • Mari, A.Institute of Neuroscience, Università di Padova (author)
  • McCarthy, M. I.Wellcome Trust Centre for Human Genetics,University of Oxford (author)
  • Walker, M.University of Newcastle upon Tyne (author)
  • McDonald, T. J.University of Exeter,Royal Devon and Exeter NHS Foundation Trust (author)
  • Perry, M. H.Royal Devon and Exeter NHS Foundation Trust (author)
  • Pearson, E. R.University of Dundee (author)
  • Franks, P. W.Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups,University of Oxford,Harvard University(Swepub:lu)med-plf (author)
  • ‘t Hart, L. M.Amsterdam UMC - Vrije Universiteit Amsterdam,Leiden University Medical Centre (author)
  • Rutters, F.Amsterdam UMC - Vrije Universiteit Amsterdam (author)
  • Amsterdam UMC - Vrije Universiteit AmsterdamUniversity Medical Center Utrecht (creator_code:org_t)
  • IMI DIRECT Consortium

Related titles

  • In:Diabetic Medicine: Wiley38:20742-30711464-5491

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