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  • Munshi, Pashna N.MedStar Georgetown University Hospital (author)

American Society of Transplantation and Cellular Therapy, Center of International Blood and Marrow Transplant Research, and European Society for Blood and Marrow Transplantation Clinical Practice Recommendations for Transplantation and Cellular Therapies in Mantle Cell Lymphoma

  • Article/chapterEnglish2021

Publisher, publication year, extent ...

  • Elsevier BV,2021
  • 9 s.

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:f9508008-e3f6-4ec4-818e-0058e7d50c69
  • https://lup.lub.lu.se/record/f9508008-e3f6-4ec4-818e-0058e7d50c69URI
  • https://doi.org/10.1016/j.jtct.2021.03.001DOI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Autologous (auto-) and allogeneic (allo-) hematopoietic cell transplantation (HCT) are accepted treatment modalities in contemporary treatment algorithms for mantle cell lymphoma (MCL). Chimeric antigen receptor (CAR) T cell therapy recently received approval for MCL; however, its exact place and sequence in relation to HCT remain unclear. The American Society of Transplantation and Cellular Therapy, Center of International Blood and Marrow Transplant Research, and the European Society for Blood and Marrow Transplantation jointly convened an expert panel to formulate consensus recommendations for role, timing, and sequencing of auto-HCT, allo-HCT, and CAR T cell therapy for patients with newly diagnosed and relapsed/refractory (R/R) MCL. The RAND-modified Delphi method was used to generate consensus statements. Seventeen consensus statements were generated, with a few key statements as follows: in the first line setting, auto-HCT consolidation represents standard of care in eligible patients, whereas there is no clear role of allo-HCT or CAR T cell therapy outside of clinical trials. In the R/R setting, the preferential option is CAR T cell therapy, especially in patients with MCL failing or intolerant to at least one Bruton's tyrosine kinase inhibitor, while allo-HCT is recommended if CAR T cell therapy fails or is infeasible. Several recommendations were based on expert opinion, where the panel developed consensus statements for important real-world clinical scenarios to guide clinical practice. In the absence of contemporary evidence-based data, the panel found RAND-modified Delphi methodology effective in providing a formal framework for developing consensus recommendations for the timing and sequence of cellular therapies for MCL.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Hamadani, MehdiMedical College of Wisconsin (author)
  • Kumar, AmbujUniversity of South Florida (author)
  • Dreger, PeterHeidelberg University (author)
  • Friedberg, Jonathan W.University of Rochester (author)
  • Dreyling, MartinUniversity Hospital Munich (author)
  • Kahl, BradWashington University in St. Louis (author)
  • Jerkeman, MatsLund University,Lunds universitet,Medicinsk onkologi,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Lymfom - Klinisk forskning,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Onkologi övergripande,Institutionen för kliniska vetenskaper, Lund,Medical oncology,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Lymphoma - Clinical Research,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Oncology corporate,Department of Clinical Sciences, Lund,Skåne University Hospital(Swepub:lu)onk-mje (author)
  • Kharfan-Dabaja, Mohamed A.Mayo Clinic Florida (author)
  • Locke, Frederick L.H. Lee Moffitt Cancer Center & Research Institute (author)
  • Shadman, MazyarFred Hutchinson Cancer Research Center (author)
  • Hill, Brian T.Cleveland Clinic Taussig Cancer Center (author)
  • Ahmed, SairahUniversity of Texas (author)
  • Herrera, Alex F.City of Hope National Medical Center (author)
  • Sauter, Craig S.Weill Cornell Medical College (author)
  • Bachanova, VeronikaUniversity of Minnesota (author)
  • Ghosh, NilanjanAtrium Health Levine Cancer Institute (author)
  • Lunning, MatthewUniversity of Nebraska Medical Center (author)
  • Kenkre, Vaishalee P.University of Wisconsin-Madison (author)
  • Aljurf, MahmoudKing Faisal Specialist Hospital and Research Centre (author)
  • Wang, MichaelUniversity of Texas (author)
  • Maddocks, Kami J.Ohio State University (author)
  • Leonard, John P.Weill Cornell Medicine (author)
  • Kamdar, ManaliUniversity of Colorado (author)
  • Phillips, TycelUniversity of Michigan Rogel Cancer Center (author)
  • Cashen, Amanda F.Washington University in St. Louis (author)
  • Inwards, David J.Mayo Clinic Minnesota (author)
  • Sureda, AnnaUniversity of Barcelona (author)
  • Cohen, Jonathon B.Emory University (author)
  • Smith, Sonali M.University of Chicago (author)
  • Carlo-Stella, CarmelloHumanitas Research Hospital (author)
  • Savani, BipinVanderbilt University (author)
  • Robinson, Stephen P.NHS Foundation Trust (author)
  • Fenske, Timothy S.Medical College of Wisconsin (author)
  • MedStar Georgetown University HospitalMedical College of Wisconsin (creator_code:org_t)

Related titles

  • In:Transplantation and cellular therapy: Elsevier BV27:9, s. 720-7282666-6367

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