SwePub
Sök i LIBRIS databas

  Utökad sökning

WFRF:(Tost Jörg)
 

Sökning: WFRF:(Tost Jörg) > (2020-2024) > Subtype and cell ty...

  • Bjørklund, Sunniva StordalNorwegian Radium Hospital,Oslo university hospital (författare)

Subtype and cell type specific expression of lncRNAs provide insight into breast cancer

  • Artikel/kapitelEngelska2022

Förlag, utgivningsår, omfång ...

  • 2022-08-18
  • Springer Science and Business Media LLC,2022

Nummerbeteckningar

  • LIBRIS-ID:oai:lup.lub.lu.se:f9814373-6038-4802-be1f-18f305cf9c19
  • https://lup.lub.lu.se/record/f9814373-6038-4802-be1f-18f305cf9c19URI
  • https://doi.org/10.1038/s42003-022-03559-7DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:art swepub-publicationtype
  • Ämneskategori:ref swepub-contenttype

Anmärkningar

  • Long non-coding RNAs (lncRNAs) are involved in breast cancer pathogenesis through chromatin remodeling, transcriptional and post-transcriptional gene regulation. We report robust associations between lncRNA expression and breast cancer clinicopathological features in two population-based cohorts: SCAN-B and TCGA. Using co-expression analysis of lncRNAs with protein coding genes, we discovered three distinct clusters of lncRNAs. In silico cell type deconvolution coupled with single-cell RNA-seq analyses revealed that these three clusters were driven by cell type specific expression of lncRNAs. In one cluster lncRNAs were expressed by cancer cells and were mostly associated with the estrogen signaling pathways. In the two other clusters, lncRNAs were expressed either by immune cells or fibroblasts of the tumor microenvironment. To further investigate the cis-regulatory regions driving lncRNA expression in breast cancer, we identified subtype-specific transcription factor (TF) occupancy at lncRNA promoters. We also integrated lncRNA expression with DNA methylation data to identify long-range regulatory regions for lncRNA which were validated using ChiA-Pet-Pol2 loops. lncRNAs play an important role in shaping the gene regulatory landscape in breast cancer. We provide a detailed subtype and cell type-specific expression of lncRNA, which improves the understanding of underlying transcriptional regulation in breast cancer.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Aure, Miriam RagleNorwegian Radium Hospital,Oslo university hospital (författare)
  • Häkkinen, JariLund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,LUCC: Lund University Cancer Centre,Other Strong Research Environments(Swepub:lu)thep-jha (författare)
  • Vallon-Christersson, JohanLund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,LUCC: Lund University Cancer Centre,Other Strong Research Environments(Swepub:lu)onk-jvc (författare)
  • Kumar, SurendraMemorial University of Newfoundland,Norwegian Radium Hospital (författare)
  • Evensen, Katrine BullNorwegian Radium Hospital (författare)
  • Fleischer, ThomasNorwegian Radium Hospital (författare)
  • Tost, JörgUniversity of Paris-Saclay (författare)
  • Sahlberg, Kristine K.Oslo university hospital,Norwegian Radium Hospital (författare)
  • Mathelier, AnthonyOslo university hospital,University of Oslo (författare)
  • Bhanot, GyanRutgers University: The State University of New Jersey,Rutgers Cancer Institute of New Jersey (författare)
  • Ganesan, ShridarRutgers Cancer Institute of New Jersey (författare)
  • Tekpli, XavierNorwegian Radium Hospital,Oslo university hospital (författare)
  • Kristensen, Vessela N.University of Oslo,Oslo university hospital (författare)
  • Norwegian Radium HospitalOslo university hospital (creator_code:org_t)
  • OSBREAC

Sammanhörande titlar

  • Ingår i:Communications Biology: Springer Science and Business Media LLC5:12399-3642

Internetlänk

Hitta via bibliotek

Till lärosätets databas

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy