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  • Ferrari, Pietro (author)

Challenges in estimating the validity of dietary acrylamide measurements

  • Article/chapterEnglish2013

Publisher, publication year, extent ...

  • 2012-11-01
  • Springer Science and Business Media LLC,2013

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:f99afb76-5015-494d-ac7e-e5e1937bc2e1
  • https://lup.lub.lu.se/record/4050289URI
  • https://doi.org/10.1007/s00394-012-0457-7DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-86278URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Acrylamide is a chemical compound present in tobacco smoke and food, classified as a probable human carcinogen and a known human neurotoxin. Acrylamide is formed in foods, typically carbohydrate-rich and protein-poor plant foods, during high-temperature cooking or other thermal processing. The objectives of this study were to compare dietary estimates of acrylamide from questionnaires (DQ) and 24-h recalls (R) with levels of acrylamide adduct (AA) in haemoglobin. In the European Prospective Investigation into Cancer and Nutrition (EPIC) study, acrylamide exposure was assessed in 510 participants from 9 European countries, randomly selected and stratified by age, sex, with equal numbers of never and current smokers. After adjusting for country, alcohol intake, smoking status, number of cigarettes and energy intake, correlation coefficients between various acrylamide measurements were computed, both at the individual and at the aggregate (centre) level. Individual level correlation coefficient between DQ and R measurements (r (DQ,R)) was 0.17, while r (DQ,AA) and r (R,AA) were 0.08 and 0.06, respectively. In never smokers, r (DQ,R), r (DQ,AA) and r (R,AA) were 0.19, 0.09 and 0.02, respectively. The correlation coefficients between means of DQ, R and AA measurements at the centre level were larger (r > 0.4). These findings suggest that estimates of total acrylamide intake based on self-reported diet correlate weakly with biomarker AA Hb levels. Possible explanations are the lack of AA levels to capture dietary acrylamide due to individual differences in the absorption and metabolism of acrylamide, and/or measurement errors in acrylamide from self-reported dietary assessments, thus limiting the possibility to validate acrylamide DQ measurements.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Freisling, Heinz (author)
  • Duell, Eric J. (author)
  • Kaaks, Rudolf (author)
  • Lujan-Barroso, Leila (author)
  • Clavel-Chapelon, Francoise (author)
  • Boutron-Ruault, Marie-Christine (author)
  • Nailler, Laura (author)
  • Polidoro, Silvia (author)
  • Mattiello, Amalia (author)
  • Palli, Domenico (author)
  • Tumino, Rosario (author)
  • Grioni, Sara (author)
  • Knueppel, Sven (author)
  • Tjonneland, Anne (author)
  • Olsen, Anja (author)
  • Overvad, Kim (author)
  • Orfanos, Philippos (author)
  • Katsoulis, Michail (author)
  • Trichopoulou, Antonia (author)
  • Ramon Quiros, Jose (author)
  • Ardanaz, Eva (author)
  • Maria Huerta, Jose (author)
  • Amiano Etxezarreta, Pilar (author)
  • Jose Sanchez, Maria (author)
  • Crowe, Francesca (author)
  • Khaw, Kay-Tee (author)
  • Wareham, Nicholas J. (author)
  • Ocke, Marga (author)
  • Bueno-de-Mesquita, Bas (author)
  • Peeters, Petra H. M. (author)
  • Ericson, UlrikaLund University,Lunds universitet,Nutritionsepidemiologi,Forskargrupper vid Lunds universitet,Nutrition Epidemiology,Lund University Research Groups(Swepub:lu)medf-upe (author)
  • Wirfält, ElisabetLund University,Lunds universitet,Nutritionsepidemiologi,Forskargrupper vid Lunds universitet,Nutrition Epidemiology,Lund University Research Groups(Swepub:lu)medf-ewi (author)
  • Hallmans, GöranUmeå universitet,Institutionen för folkhälsa och klinisk medicin(Swepub:umu)goha0001 (author)
  • Johansson, IngegerdUmeå universitet,Institutionen för odontologi,Enheten för biobanksforskning(Swepub:umu)injo0003 (author)
  • Engeset, Dagrun (author)
  • Nicolas, Genevieve (author)
  • Gallo, Valentina (author)
  • Norat, Teresa (author)
  • Riboli, Elio (author)
  • Slimani, Nadia (author)
  • NutritionsepidemiologiForskargrupper vid Lunds universitet (creator_code:org_t)

Related titles

  • In:European Journal of Nutrition: Springer Science and Business Media LLC52:5, s. 1503-15121436-62151436-6207

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