SwePub
Sök i LIBRIS databas

  Extended search

WFRF:(Virtanen Suvi M.)
 

Search: WFRF:(Virtanen Suvi M.) > (2020-2024) > 25(OH)D Levels in I...

25(OH)D Levels in Infancy Is Associated With Celiac Disease Autoimmunity in At-Risk Children : A Case–Control Study

Andrén Aronsson, Carin (author)
Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups
Liu, Xiang (author)
University of South Florida
Norris, Jill M. (author)
Colorado School of Public Health
show more...
Uusitalo, Ulla (author)
University of South Florida
Butterworth, Martha D. (author)
University of South Florida
Koletzko, Sibylle (author)
University Hospital Munich,University of Warmia and Mazury
Virtanen, Suvi M. (author)
Finnish National Institute for Health and Welfare,University of Tampere
Erlund, Iris (author)
Finnish National Institute for Health and Welfare
Kurppa, Kalle (author)
South Ostrobothnia Central Hospital,University of Tampere,Tampere University Hospital
Hagopian, William A. (author)
Pacific Northwest Research Institute
Rewers, Marian J. (author)
Barbara Davis Center for Childhood Diabetes
She, Jin Xiong (author)
Medical College of Georgia
Toppari, Jorma (author)
University of Turku,Turku University Hospital
Ziegler, Anette G. (author)
Klinikum rechts der Isar
Akolkar, Beena (author)
National Institute of Diabetes and Digestive and Kidney Diseases
Krischer, Jeffrey P. (author)
University of South Florida
Agardh, Daniel (author)
Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups
show less...
 (creator_code:org_t)
 
2021-08-11
2021
English.
In: Frontiers in Nutrition. - : Frontiers Media SA. - 2296-861X. ; 8
  • Journal article (peer-reviewed)
Abstract Subject headings
Close  
  • Objectives: An observed variation in the risk of celiac disease, according to the season of birth, suggests that vitamin D may affect the development of the disease. The aim of this study was to investigate if vitamin D concentration is associated with the risk of celiac disease autoimmunity (CDA) in genetically at-risk children. Study Design: Children prospectively followed in the multinational The Environmental Determinants of Diabetes in the Young study, conducted at six centers in Europe and the US, were selected for a 1-to-3 nested case–control study. In total, 281 case–control sets were identified. CDA was defined as positivity for tissue transglutaminase autoantibodies (tTGA) on two or more consecutive visits. Vitamin D was measured as 25-hydroxyvitamin D [25(OH)D] concentrations in all plasma samples prior to, and including, the first tTGA positive visit. Conditional logistic regression was used to examine the association between 25(OH)D and risk of CDA. Results: No significant association was seen between 25(OH)D concentrations (per 5 nmol/L increase) and risk for CDA development during early infancy (odds ratio [OR] 0.99, 95% confidence interval [CI] 0.95–1.04) or childhood (OR 1.02, 95% CI 0.97–1.07). When categorizing 25(OH)D concentrations, there was an increased risk of CDA with 25(OH)D concentrations <30 nmol/L (OR 2.23, 95% CI 1.29, 3.84) and >75 nmol/L (OR 2.10, 95% CI 1.28–3.44) in early infancy, as compared with 50–75 nmol/L. Conclusion: This study indicates that 25(OH)D concentrations <30 nmol/L and >75 nmol/L during early infancy were associated with an increased risk of developing CDA in genetically at-risk children. The non-linear relationship raises the need for more studies on the possible role of 25(OH)D in the relation to celiac disease onset.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Hälsovetenskap -- Näringslära (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Health Sciences -- Nutrition and Dietetics (hsv//eng)

Keyword

celiac disease
celiac disease autoimmunity
children
infants
TEDDY
vitamin D

Publication and Content Type

art (subject category)
ref (subject category)

Find in a library

To the university's database

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view