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Sökning: WFRF:(Virtanen Suvi M.) > (2020-2024) > 25(OH)D Levels in I...

  • Andrén Aronsson, CarinLund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups (författare)

25(OH)D Levels in Infancy Is Associated With Celiac Disease Autoimmunity in At-Risk Children : A Case–Control Study

  • Artikel/kapitelEngelska2021

Förlag, utgivningsår, omfång ...

  • 2021-08-11
  • Frontiers Media SA,2021

Nummerbeteckningar

  • LIBRIS-ID:oai:lup.lub.lu.se:f9d63d05-31b5-4caa-8860-86cb718df3af
  • https://lup.lub.lu.se/record/f9d63d05-31b5-4caa-8860-86cb718df3afURI
  • https://doi.org/10.3389/fnut.2021.720041DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

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Klassifikation

  • Ämneskategori:art swepub-publicationtype
  • Ämneskategori:ref swepub-contenttype

Anmärkningar

  • Objectives: An observed variation in the risk of celiac disease, according to the season of birth, suggests that vitamin D may affect the development of the disease. The aim of this study was to investigate if vitamin D concentration is associated with the risk of celiac disease autoimmunity (CDA) in genetically at-risk children. Study Design: Children prospectively followed in the multinational The Environmental Determinants of Diabetes in the Young study, conducted at six centers in Europe and the US, were selected for a 1-to-3 nested case–control study. In total, 281 case–control sets were identified. CDA was defined as positivity for tissue transglutaminase autoantibodies (tTGA) on two or more consecutive visits. Vitamin D was measured as 25-hydroxyvitamin D [25(OH)D] concentrations in all plasma samples prior to, and including, the first tTGA positive visit. Conditional logistic regression was used to examine the association between 25(OH)D and risk of CDA. Results: No significant association was seen between 25(OH)D concentrations (per 5 nmol/L increase) and risk for CDA development during early infancy (odds ratio [OR] 0.99, 95% confidence interval [CI] 0.95–1.04) or childhood (OR 1.02, 95% CI 0.97–1.07). When categorizing 25(OH)D concentrations, there was an increased risk of CDA with 25(OH)D concentrations <30 nmol/L (OR 2.23, 95% CI 1.29, 3.84) and >75 nmol/L (OR 2.10, 95% CI 1.28–3.44) in early infancy, as compared with 50–75 nmol/L. Conclusion: This study indicates that 25(OH)D concentrations <30 nmol/L and >75 nmol/L during early infancy were associated with an increased risk of developing CDA in genetically at-risk children. The non-linear relationship raises the need for more studies on the possible role of 25(OH)D in the relation to celiac disease onset.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Liu, XiangUniversity of South Florida (författare)
  • Norris, Jill M.Colorado School of Public Health (författare)
  • Uusitalo, UllaUniversity of South Florida (författare)
  • Butterworth, Martha D.University of South Florida (författare)
  • Koletzko, SibylleUniversity Hospital Munich,University of Warmia and Mazury (författare)
  • Virtanen, Suvi M.Finnish National Institute for Health and Welfare,University of Tampere (författare)
  • Erlund, IrisFinnish National Institute for Health and Welfare (författare)
  • Kurppa, KalleSouth Ostrobothnia Central Hospital,University of Tampere,Tampere University Hospital (författare)
  • Hagopian, William A.Pacific Northwest Research Institute (författare)
  • Rewers, Marian J.Barbara Davis Center for Childhood Diabetes (författare)
  • She, Jin XiongMedical College of Georgia (författare)
  • Toppari, JormaUniversity of Turku,Turku University Hospital (författare)
  • Ziegler, Anette G.Klinikum rechts der Isar (författare)
  • Akolkar, BeenaNational Institute of Diabetes and Digestive and Kidney Diseases (författare)
  • Krischer, Jeffrey P.University of South Florida (författare)
  • Agardh, DanielLund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups(Swepub:lu)med-dia (författare)
  • Celiaki och diabetesForskargrupper vid Lunds universitet (creator_code:org_t)
  • TEDDY Study Group

Sammanhörande titlar

  • Ingår i:Frontiers in Nutrition: Frontiers Media SA82296-861X

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