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25(OH)D Levels in I...
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Andrén Aronsson, CarinLund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups
(författare)
25(OH)D Levels in Infancy Is Associated With Celiac Disease Autoimmunity in At-Risk Children : A Case–Control Study
- Artikel/kapitelEngelska2021
Förlag, utgivningsår, omfång ...
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2021-08-11
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Frontiers Media SA,2021
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LIBRIS-ID:oai:lup.lub.lu.se:f9d63d05-31b5-4caa-8860-86cb718df3af
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https://lup.lub.lu.se/record/f9d63d05-31b5-4caa-8860-86cb718df3afURI
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https://doi.org/10.3389/fnut.2021.720041DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:art swepub-publicationtype
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Ämneskategori:ref swepub-contenttype
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Objectives: An observed variation in the risk of celiac disease, according to the season of birth, suggests that vitamin D may affect the development of the disease. The aim of this study was to investigate if vitamin D concentration is associated with the risk of celiac disease autoimmunity (CDA) in genetically at-risk children. Study Design: Children prospectively followed in the multinational The Environmental Determinants of Diabetes in the Young study, conducted at six centers in Europe and the US, were selected for a 1-to-3 nested case–control study. In total, 281 case–control sets were identified. CDA was defined as positivity for tissue transglutaminase autoantibodies (tTGA) on two or more consecutive visits. Vitamin D was measured as 25-hydroxyvitamin D [25(OH)D] concentrations in all plasma samples prior to, and including, the first tTGA positive visit. Conditional logistic regression was used to examine the association between 25(OH)D and risk of CDA. Results: No significant association was seen between 25(OH)D concentrations (per 5 nmol/L increase) and risk for CDA development during early infancy (odds ratio [OR] 0.99, 95% confidence interval [CI] 0.95–1.04) or childhood (OR 1.02, 95% CI 0.97–1.07). When categorizing 25(OH)D concentrations, there was an increased risk of CDA with 25(OH)D concentrations <30 nmol/L (OR 2.23, 95% CI 1.29, 3.84) and >75 nmol/L (OR 2.10, 95% CI 1.28–3.44) in early infancy, as compared with 50–75 nmol/L. Conclusion: This study indicates that 25(OH)D concentrations <30 nmol/L and >75 nmol/L during early infancy were associated with an increased risk of developing CDA in genetically at-risk children. The non-linear relationship raises the need for more studies on the possible role of 25(OH)D in the relation to celiac disease onset.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Liu, XiangUniversity of South Florida
(författare)
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Norris, Jill M.Colorado School of Public Health
(författare)
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Uusitalo, UllaUniversity of South Florida
(författare)
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Butterworth, Martha D.University of South Florida
(författare)
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Koletzko, SibylleUniversity Hospital Munich,University of Warmia and Mazury
(författare)
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Virtanen, Suvi M.Finnish National Institute for Health and Welfare,University of Tampere
(författare)
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Erlund, IrisFinnish National Institute for Health and Welfare
(författare)
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Kurppa, KalleSouth Ostrobothnia Central Hospital,University of Tampere,Tampere University Hospital
(författare)
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Hagopian, William A.Pacific Northwest Research Institute
(författare)
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Rewers, Marian J.Barbara Davis Center for Childhood Diabetes
(författare)
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She, Jin XiongMedical College of Georgia
(författare)
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Toppari, JormaUniversity of Turku,Turku University Hospital
(författare)
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Ziegler, Anette G.Klinikum rechts der Isar
(författare)
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Akolkar, BeenaNational Institute of Diabetes and Digestive and Kidney Diseases
(författare)
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Krischer, Jeffrey P.University of South Florida
(författare)
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Agardh, DanielLund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups(Swepub:lu)med-dia
(författare)
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Celiaki och diabetesForskargrupper vid Lunds universitet
(creator_code:org_t)
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TEDDY Study Group
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Ingår i:Frontiers in Nutrition: Frontiers Media SA82296-861X
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She, Jin Xiong
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