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- Hermansen, Russell A (author)
Characterizing selective pressures on the pathway for de novo biosynthesis of pyrimidines in yeast.
- Article/chapterEnglish2015
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- 2015-10-28
- Springer Science and Business Media LLC,2015
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- LIBRIS-ID:oai:lup.lub.lu.se:f9e87541-ca18-422b-b68f-73e8e0715e5f
- https://lup.lub.lu.se/record/8148026URI
- https://doi.org/10.1186/s12862-015-0515-xDOI
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- Language:English
- Summary in:English
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- Selection on proteins is typically measured with the assumption that each protein acts independently. However, selection more likely acts at higher levels of biological organization, requiring an integrative view of protein function. Here, we built a kinetic model for de novo pyrimidine biosynthesis in the yeast Saccharomyces cerevisiae to relate pathway function to selective pressures on individual protein-encoding genes.
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- Mannakee, Brian K (author)
- Knecht, WolfgangLund University,Lunds universitet,Molekylär cellbiologi,Biologiska institutionen,Naturvetenskapliga fakulteten,Molecular Cell Biology,Department of Biology,Faculty of Science(Swepub:lu)biol-wnk (author)
- Liberles, David A (author)
- Gutenkunst, Ryan N (author)
- Molekylär cellbiologiBiologiska institutionen (creator_code:org_t)
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- In:BMC Evolutionary Biology: Springer Science and Business Media LLC151471-2148
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