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Complement C4d-spec...
Complement C4d-specific antibodies for the diagnosis of lung cancer
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- Ajona, Daniel (författare)
- Health Research Institute of Navarra (IDISNA),Spanish Center for Biomedical Research Network in Oncology (CIBERONC),University of Navarra
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- Okrój, Marcin (författare)
- Lund University,Lunds universitet,Proteinkemi, Malmö,Forskargrupper vid Lunds universitet,Protein Chemistry, Malmö,Lund University Research Groups,Medical University of Gdansk
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- Pajares, María J. (författare)
- University of Navarra,Spanish Center for Biomedical Research Network in Oncology (CIBERONC),Health Research Institute of Navarra (IDISNA)
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- Agorreta, Jackeline (författare)
- Health Research Institute of Navarra (IDISNA),University of Navarra,Spanish Center for Biomedical Research Network in Oncology (CIBERONC)
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- Lozano, María D. (författare)
- University of Navarra
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- Zulueta, Javier J. (författare)
- University of Navarra
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- Verri, Carla (författare)
- Istituto Nazionale dei Tumori
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- Roz, Luca (författare)
- Istituto Nazionale dei Tumori
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- Sozzi, Gabriella (författare)
- Istituto Nazionale dei Tumori
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- Pastorino, Ugo (författare)
- Istituto Nazionale dei Tumori
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- Massion, Pierre P. (författare)
- Vanderbilt University
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- Montuenga, Luis M. (författare)
- Health Research Institute of Navarra (IDISNA),University of Navarra,Spanish Center for Biomedical Research Network in Oncology (CIBERONC)
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- Blom, Anna M. (författare)
- Lund University,Lunds universitet,Proteinkemi, Malmö,Forskargrupper vid Lunds universitet,Protein Chemistry, Malmö,Lund University Research Groups
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- Pio, Ruben (författare)
- University of Navarra,Spanish Center for Biomedical Research Network in Oncology (CIBERONC),Health Research Institute of Navarra (IDISNA)
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(creator_code:org_t)
- 2017-12-26
- 2018
- Engelska 10 s.
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Ingår i: Oncotarget. - : Impact Journals, LLC. - 1949-2553. ; 9:5, s. 6346-6355
- Relaterad länk:
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http://dx.doi.org/10...
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http://www.oncotarge...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Development of molecular markers that help to identify high-risk individuals or diagnose indeterminate pulmonary nodules could have a major impact on lung cancer clinical management. In this study, we evaluated the diagnostic potential of a newly-developed ELISA that specifically detects complement C4d. We measured this marker in five independent cohorts of plasma and bronchoalveolar lavage samples from lung cancer patients and controls. In case-control studies, the area under the ROC curve for the diagnosis of lung cancer was 0.82 (95%CI = 0.72-0.92) in plasma samples, and 0.80 (95%CI = 0.69 to 0.90) in bronchoalveolar lavage fluids. In a set of plasma samples from the MILD CT-screening trial, the assay was unable to discriminate between asymptomatic high-risk individuals with or without early stage lung cancer. On the contrary, in two independent cohorts of individuals with indeterminate pulmonary nodules, plasma samples from patients with lung cancer nodules presented higher levels of C4d than those from patients with benign nodules. Using a target population of patients with 8 to 30 mm nodules, the test identified likely benign lung nodules with 84% negative predictive value and 54% positive predictive value, at 89% specificity and 44% sensitivity. In conclusion, the specific determination of C4d may serve as an adjunct to current clinical practice in the diagnosis of indeterminate pulmonary nodules.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- Biomarker
- Complement C4d
- Diagnosis
- Indeterminate pulmonary nodules
- Lung cancer
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Ajona, Daniel
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Okrój, Marcin
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Pajares, María J ...
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Agorreta, Jackel ...
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Lozano, María D.
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Zulueta, Javier ...
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visa fler...
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Verri, Carla
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Roz, Luca
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Sozzi, Gabriella
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Pastorino, Ugo
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Massion, Pierre ...
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Montuenga, Luis ...
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Blom, Anna M.
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Pio, Ruben
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Cancer och onkol ...
- Artiklar i publikationen
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Oncotarget
- Av lärosätet
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Lunds universitet