Search: ((WFRF:(Sud Amit)) pers:(Swerdlow Anthony J)) srt2:(2018) >
Genome-wide associa...
Genome-wide association study implicates immune dysfunction in the development of Hodgkin lymphoma
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- Sud, Amit (author)
- Institute of Cancer Research London
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- Thomsen, Hauke (author)
- German Cancer Research Centre
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- Orlando, Giulia (author)
- Institute of Cancer Research London
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- Försti, Asta (author)
- Lund University,Lunds universitet,Allmänmedicin och klinisk epidemiologi,Forskargrupper vid Lunds universitet,Family Medicine and Clinical Epidemiology,Lund University Research Groups
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- Law, Philip J (author)
- Institute of Cancer Research London
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- Broderick, Peter (author)
- Institute of Cancer Research London
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- Cooke, Rosie (author)
- Institute of Cancer Research London
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- Hariri, Fadi (author)
- McGill University
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- Pastinen, Tomi (author)
- McGill University
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- Easton, Douglas F (author)
- University of Cambridge
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- Pharoah, Paul D P (author)
- University of Cambridge
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- Dunning, Alison M (author)
- University of Cambridge
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- Peto, Julian (author)
- London School of Hygiene and Tropical Medicine
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- Canzian, Federico (author)
- German Cancer Research Centre
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- Eeles, Rosalind (author)
- Royal Marsden NHS Foundation Trust
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- Kote-Jarai, ZSofia (author)
- Institute of Cancer Research London
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- Muir, Kenneth (author)
- University of Manchester
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- Pashayan, Nora (author)
- University College London
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- Campa, Daniele (author)
- University of Pisa
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- Hoffmann, Per (author)
- University of Basel
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- Nöthen, Markus M (author)
- University of Bonn
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- Jöckel, Karl-Heinz (author)
- University of Duisburg-Essen
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- von Strandmann, Elke Pogge (author)
- Philipp University of Marburg
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- Swerdlow, Anthony J (author)
- Institute of Cancer Research London
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- Engert, Andreas (author)
- University Hospital of Cologne
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- Orr, Nick (author)
- Institute of Cancer Research London
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- Hemminki, Kari (author)
- German Cancer Research Centre
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- Houlston, Richard S (author)
- Institute of Cancer Research London
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(creator_code:org_t)
- American Society of Hematology, 2018
- 2018
- English.
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In: Blood. - : American Society of Hematology. - 1528-0020 .- 0006-4971. ; 132:19, s. 2040-2052
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http://dx.doi.org/10...
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Abstract
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- To further our understanding of inherited susceptibility to Hodgkin lymphoma (HL), we performed a meta-analysis of seven genome-wide association studies totalling 5,325 HL cases and 22,423 controls. We identify five new HL risk loci at 6p21.31 (rs649775, P = 2.11 × 10-10), 6q23.3 (rs1002658, P = 2.97 × 10-8), 11q23.1 (rs7111520, P = 1.44 × 10-11), 16p11.2 (rs6565176, P = 4.00 × 10-8) and 20q13.12 (rs2425752, P = 2.01 × 10-8). Integration of gene expression, histone modification and in situ promoter capture Hi-C data at the five new and 13 known risk loci implicates dysfunction of the germinal centre reaction, disrupted T-cell differentiation and function, and constitutive NF-κB activation as mechanisms of predisposition. These data provide further insights into the genetic susceptibility and biology of HL.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
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- ref (subject category)
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Blood
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- By the author/editor
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Sud, Amit
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Thomsen, Hauke
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Orlando, Giulia
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Försti, Asta
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Law, Philip J
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Broderick, Peter
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show more...
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Cooke, Rosie
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Hariri, Fadi
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Pastinen, Tomi
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Easton, Douglas ...
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Pharoah, Paul D ...
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Dunning, Alison ...
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Peto, Julian
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Canzian, Federic ...
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Eeles, Rosalind
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Kote-Jarai, ZSof ...
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Muir, Kenneth
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Pashayan, Nora
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Campa, Daniele
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Hoffmann, Per
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Nöthen, Markus M
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Jöckel, Karl-Hei ...
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von Strandmann, ...
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Swerdlow, Anthon ...
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Engert, Andreas
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Orr, Nick
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Hemminki, Kari
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Houlston, Richar ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Medical Genetics
- Articles in the publication
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Blood
- By the university
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Lund University