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  • Eliasson, Lena (author)

PKC-dependent stimulation of exocytosis by sulfonylureas in pancreatic beta cells

  • Article/chapterEnglish1996

Publisher, publication year, extent ...

  • American Association for the Advancement of Science (AAAS),1996

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:fb786f9b-4b04-460f-b94b-bdb528300381
  • https://lup.lub.lu.se/record/1109849URI
  • https://doi.org/10.1126/science.271.5250.813DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:1928785URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Hypoglycemic sulfonylureas represent a group of clinically useful antidiabetic compounds that stimulate insulin secretion from pancreatic beta cells. The molecular mechanisms involved are not fully understood but are believed to involve inhibition of potassium channels sensitive to adenosine triphosphate (KATP channels) in the beta cell membrane, causing membrane depolarization, calcium influx, and activation of the secretory machinery. In addition to these effects, sulfonylureas also promoted exocytosis by direct interaction with the secretory machinery not involving closure of the plasma membrane KATP channels. This effect was dependent on protein kinase C (PKC) and was observed at therapeutic concentrations of sulfonylureas, which suggests that it contributes to their hypoglycemic action in diabetics.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Renström, ErikLund University,Lunds universitet,Diabetes - öpatofysiologi,Forskargrupper vid Lunds universitet,Diabetes - Islet Patophysiology,Lund University Research Groups(Swepub:lu)mphy-ere (author)
  • Ammala, Carina (author)
  • Berggren, Per-OlofKarolinska Institutet (author)
  • Bertorello, Alejandro M.Karolinska Institutet (author)
  • Bokvist, Krister (author)
  • Chibalin, AlexanderKarolinska Institutet (author)
  • Deeney, Jude T. (author)
  • Flatt, Peter R. (author)
  • Gabel, Jakob (author)
  • Gromada, Jesper (author)
  • Larsson, Olof (author)
  • Lindstrom, Per (author)
  • Rhodes, Christopher J. (author)
  • Rorsman, Patrik (author)
  • Diabetes - öpatofysiologiForskargrupper vid Lunds universitet (creator_code:org_t)

Related titles

  • In:Science: American Association for the Advancement of Science (AAAS)271:5250, s. 813-8151095-92030036-8075

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