Search: L773:0894 1491 OR L773:1098 1136 >
Multimodal single-c...
Multimodal single-cell analysis reveals distinct radioresistant stem-like and progenitor cell populations in murine glioma
-
- Alexander, Jes (author)
- University of Washington
-
- LaPlant, Quincey C. (author)
- Memorial Sloan-Kettering Cancer Center
-
- Pattwell, Siobhan S. (author)
- Fred Hutchinson Cancer Research Center
-
show more...
-
- Szulzewsky, Frank (author)
- Fred Hutchinson Cancer Research Center
-
- Cimino, Patrick J. (author)
- Fred Hutchinson Cancer Research Center
-
- Caruso, Francesca P. (author)
- Biogem,University of Sannio
-
- Pugliese, Pietro (author)
- University of Sannio,Biogem
-
- Chen, Zhihong (author)
- Icahn School of Medicine at Mount Sinai
-
- Chardon, Florence (author)
- University of Washington
-
- Hill, Andrew J. (author)
- University of Washington
-
- Spurrell, Cailyn (author)
- Brotman Baty Institute
-
- Ahrendsen, Dakota (author)
- Brotman Baty Institute
-
- Pietras, Alexander (author)
- Lund University,Lunds universitet,Hjärntumörers biologi,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Brain Tumor Biology,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments
-
- Starita, Lea M. (author)
- University of Washington,Brotman Baty Institute
-
- Hambardzumyan, Dolores (author)
- Icahn School of Medicine at Mount Sinai
-
- Iavarone, Antonio (author)
- Columbia University
-
- Shendure, Jay (author)
- Brotman Baty Institute,Allen Discovery Center for Cell Lineage Tracing,University of Washington
-
- Holland, Eric C. (author)
- Fred Hutchinson Cancer Research Center
-
show less...
-
(creator_code:org_t)
- 2020-07-04
- 2020
- English 17 s.
-
In: GLIA. - : Wiley. - 0894-1491 .- 1098-1136. ; 68:12, s. 2486-2502
- Related links:
-
http://dx.doi.org/10... (free)
-
show more...
-
https://onlinelibrar...
-
https://lup.lub.lu.s...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- Radiation therapy is part of the standard of care for gliomas and kills a subset of tumor cells, while also altering the tumor microenvironment. Tumor cells with stem-like properties preferentially survive radiation and give rise to glioma recurrence. Various techniques for enriching and quantifying cells with stem-like properties have been used, including the fluorescence activated cell sorting (FACS)-based side population (SP) assay, which is a functional assay that enriches for stem-like tumor cells. In these analyses, mouse models of glioma have been used to understand the biology of this disease and therapeutic responses, including the radiation response. We present combined SP analysis and single-cell RNA sequencing of genetically-engineered mouse models of glioma to show a time course of cellular response to radiation. We identify and characterize two distinct tumor cell populations that are inherently radioresistant and also distinct effects of radiation on immune cell populations within the tumor microenvironment.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Keyword
- glioma
- glioma stem cells
- myeloid cells
- radiation response
- radioresistance
- single-cell RNA sequencing
- SP analysis
Publication and Content Type
- art (subject category)
- ref (subject category)
Find in a library
-
GLIA
(Search for host publication in LIBRIS)
To the university's database
- By the author/editor
-
Alexander, Jes
-
LaPlant, Quincey ...
-
Pattwell, Siobha ...
-
Szulzewsky, Fran ...
-
Cimino, Patrick ...
-
Caruso, Francesc ...
-
show more...
-
Pugliese, Pietro
-
Chen, Zhihong
-
Chardon, Florenc ...
-
Hill, Andrew J.
-
Spurrell, Cailyn
-
Ahrendsen, Dakot ...
-
Pietras, Alexand ...
-
Starita, Lea M.
-
Hambardzumyan, D ...
-
Iavarone, Antoni ...
-
Shendure, Jay
-
Holland, Eric C.
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Cancer and Oncol ...
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Basic Medicine
-
and Cell and Molecul ...
- Articles in the publication
-
GLIA
- By the university
-
Lund University