Search: L773:1600 0773 OR L773:0901 9928 >
Human fibroblasts l...
-
Pessah-Rasmussen, HLund University,Lunds universitet,Rehabiliteringsmedicin,Forskargrupper vid Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Rehabilitation medicine,Lund University Research Groups,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital
(author)
Human fibroblasts lacking trans-stilbene oxide active glutathione transferase exhibit increased cell death when exposed to polycyclic aromatic hydrocarbons
- Article/chapterEnglish1992
Publisher, publication year, extent ...
Numbers
-
LIBRIS-ID:oai:lup.lub.lu.se:fc292e60-e29d-427c-a41f-32af0f2003ba
-
https://lup.lub.lu.se/record/fc292e60-e29d-427c-a41f-32af0f2003baURI
-
https://doi.org/10.1111/j.1600-0773.1992.tb00488.xDOI
Supplementary language notes
-
Language:English
-
Summary in:English
Part of subdatabase
Classification
-
Subject category:art swepub-publicationtype
-
Subject category:ref swepub-contenttype
Notes
-
Glutathione transferases (GST) are detoxifying enzymes who act with many endogenous and exogenous substances such as polycyclic aromatic hydrocarbons (PAH). The GST activity towards trans-stilbene oxide (GST-tSBO) is inherited in an autosomal dominant fashion and can be separated in high (GST-positive) and low (GST-negative) phenotypes when measured in blood. Human fibroblast cultures were established from males matched for age, smoking habits and clinical manifestations of atherosclerosis. Matched pairs of GST-negative and GST-positive fibroblasts were studied. There was a very strong correlation between the levels of GST-tSBO in peripheral blood and in cultured fibroblasts within the same individual. When fibroblasts were exposed to benzo(a)pyrene (BP) or dimethylbenzanthracene (DMBA) GST-negative cells produced relatively more collagen than GST-positive cells. GST-negative fibroblasts showed a greater cell death than GST-positive fibroblasts as well among controls as after exposure to PAH. It is concluded that lack of GST-tSBO is easily discriminated in cultured skin fibroblasts. GST-negative and GST-positive fibroblasts showed different susceptibility towards some toxic stimuli that might be of importance in atherogenesis.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
-
Stavenow, L.
(author)
-
Seidegård, JLund University,Lunds universitet,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Section V,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)extLU-263
(author)
-
Berglund, Anna
(author)
-
RehabiliteringsmedicinForskargrupper vid Lunds universitet
(creator_code:org_t)
Related titles
-
In:Pharmacology and Toxicology: Wiley70:5 Pt 1, s. 5-3610901-99281600-0773
Internet link
Find in a library
To the university's database