Neuropsychiatric and Cognitive Symptoms Across the Alzheimer Disease Clinical Spectrum: Cross-sectional and Longitudinal Associations

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Search: WFRF:(Coesmans Michiel) > (2021) > Neuropsychiatric an...

1 of 1
Previous record
Next record
To hitlist

Details
MARC

Eikelboom, Willem S.Erasmus University Medical Center (author)

Neuropsychiatric and Cognitive Symptoms Across the Alzheimer Disease Clinical Spectrum: Cross-sectional and Longitudinal Associations

Article/chapterEnglish2021

Publisher, publication year, extent ...

2021

Numbers

LIBRIS-ID:oai:lup.lub.lu.se:fc409cd3-1a0d-4de9-9d85-564e4ea79ce9
https://lup.lub.lu.se/record/fc409cd3-1a0d-4de9-9d85-564e4ea79ce9URI
https://doi.org/10.1212/WNL.0000000000012598DOI

Supplementary language notes

Language:English
Summary in:English

Part of subdatabase

SwePubSwePub

Classification

Subject category:art swepub-publicationtype
Subject category:ref swepub-contenttype

Notes

BACKGROUND AND OBJECTIVES: To investigate the prevalence and trajectories of neuropsychiatric symptoms (NPS) in relation to cognitive functioning in a cohort of β-amyloid-positive (A+) individuals across the Alzheimer disease (AD) clinical spectrum. METHODS: In this single-center observational study, we included all individuals who visited the Alzheimer Center Amsterdam and had a clinical diagnosis of subjective cognitive decline (SCD), mild cognitive impairment (MCI), or probable AD dementia and were A+. We measured NPS with the Neuropsychiatric Inventory (NPI), examining total scores and the presence of specific NPI domains. Cognition was assessed across 5 cognitive domains and with the Mini-Mental State Examination (MMSE). We examined trajectories including model-based trends for NPS and cognitive functioning over time. We used linear mixed models to relate baseline NPI scores to cognitive functioning at baseline (whole-sample) and longitudinal time points (subsample n = 520, mean 1.8 [SD 0.7] years follow-up). RESULTS: We included 1,524 A+ individuals from the Amsterdam Dementia Cohort with A+ SCD (n = 113), A+ MCI (n = 321), or A+ AD dementia (n = 1,090). NPS were prevalent across all clinical AD stages (≥1 NPS 81.4% in SCD, 81.2% in MCI, 88.7% in dementia; ≥1 clinically relevant NPS 54.0% in SCD, 50.5% in MCI, 66.0% in dementia). Cognitive functioning showed a uniform gradual decline; while in contrast, large intraindividual heterogeneity of NPS was observed over time across all AD groups. At baseline, we found associations between NPS and cognition in dementia that were most pronounced for NPI total scores and MMSE (range β = -0.18 to -0.11, false discovery rate [FDR]-adjusted p < 0.05), while there were no cross-sectional relationships in SCD and MCI (range β = -0.32 to 0.36, all FDR-adjusted p > 0.05). There were no associations between baseline NPS and cognitive functioning over time in any clinical stage (range β = -0.13 to 0.44, all FDR-adjusted p > 0.05). DISCUSSION: NPS and cognitive symptoms are both prevalent across the AD clinical spectrum, but show a different evolution during the course of the disease.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Neurologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Neurology hsv//eng

Added entries (persons, corporate bodies, meetings, titles ...)

van den Berg, EstherErasmus University Medical Center (author)
Singleton, Ellen H.Erasmus University Medical Center (author)
Baart, Sara J.Erasmus University Medical Center (author)
Coesmans, MichielErasmus University Medical Center (author)
Leeuwis, Annebet E. (author)
Teunissen, Charlotte E. (author)
van Berckel, Bart N.M. (author)
Pijnenburg, Yolande A.L. (author)
Scheltens, Philip (author)
van der Flier, Wiesje M. (author)
Ossenkoppele, RikLund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Erasmus University Medical Center(Swepub:lu)ri1513os (author)
Papma, Janne M. (author)
Erasmus University Medical CenterKlinisk minnesforskning (creator_code:org_t)

Related titles

In:Neurology97:13, s. 1276-12871526-632X

Internet link

Find in a library

Neurology (Search for host publication in LIBRIS)

To the university's database

1 of 1
Previous record
Next record
To hitlist

Find more in SwePub

By the author/editor: Eikelboom, Wille ...; van den Berg, Es ...; Singleton, Ellen ...; Baart, Sara J.; Coesmans, Michie ...; Leeuwis, Annebet ...; show more...; Teunissen, Charl ...; van Berckel, Bar ...; Pijnenburg, Yola ...; Scheltens, Phili ...; van der Flier, W ...; Ossenkoppele, Ri ...; Papma, Janne M.; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Neurology

Articles in the publication: Neurology

By the university: Lund University

Search outside SwePub

Extend your search to:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se