SwePub
Sök i LIBRIS databas

  Utökad sökning

onr:"swepub:oai:lup.lub.lu.se:fc409cd3-1a0d-4de9-9d85-564e4ea79ce9"
 

Sökning: onr:"swepub:oai:lup.lub.lu.se:fc409cd3-1a0d-4de9-9d85-564e4ea79ce9" > Neuropsychiatric an...

  • Eikelboom, Willem S.Erasmus University Medical Center (författare)

Neuropsychiatric and Cognitive Symptoms Across the Alzheimer Disease Clinical Spectrum: Cross-sectional and Longitudinal Associations

  • Artikel/kapitelEngelska2021

Förlag, utgivningsår, omfång ...

  • 2021

Nummerbeteckningar

  • LIBRIS-ID:oai:lup.lub.lu.se:fc409cd3-1a0d-4de9-9d85-564e4ea79ce9
  • https://lup.lub.lu.se/record/fc409cd3-1a0d-4de9-9d85-564e4ea79ce9URI
  • https://doi.org/10.1212/WNL.0000000000012598DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:art swepub-publicationtype
  • Ämneskategori:ref swepub-contenttype

Anmärkningar

  • BACKGROUND AND OBJECTIVES: To investigate the prevalence and trajectories of neuropsychiatric symptoms (NPS) in relation to cognitive functioning in a cohort of β-amyloid-positive (A+) individuals across the Alzheimer disease (AD) clinical spectrum. METHODS: In this single-center observational study, we included all individuals who visited the Alzheimer Center Amsterdam and had a clinical diagnosis of subjective cognitive decline (SCD), mild cognitive impairment (MCI), or probable AD dementia and were A+. We measured NPS with the Neuropsychiatric Inventory (NPI), examining total scores and the presence of specific NPI domains. Cognition was assessed across 5 cognitive domains and with the Mini-Mental State Examination (MMSE). We examined trajectories including model-based trends for NPS and cognitive functioning over time. We used linear mixed models to relate baseline NPI scores to cognitive functioning at baseline (whole-sample) and longitudinal time points (subsample n = 520, mean 1.8 [SD 0.7] years follow-up). RESULTS: We included 1,524 A+ individuals from the Amsterdam Dementia Cohort with A+ SCD (n = 113), A+ MCI (n = 321), or A+ AD dementia (n = 1,090). NPS were prevalent across all clinical AD stages (≥1 NPS 81.4% in SCD, 81.2% in MCI, 88.7% in dementia; ≥1 clinically relevant NPS 54.0% in SCD, 50.5% in MCI, 66.0% in dementia). Cognitive functioning showed a uniform gradual decline; while in contrast, large intraindividual heterogeneity of NPS was observed over time across all AD groups. At baseline, we found associations between NPS and cognition in dementia that were most pronounced for NPI total scores and MMSE (range β = -0.18 to -0.11, false discovery rate [FDR]-adjusted p < 0.05), while there were no cross-sectional relationships in SCD and MCI (range β = -0.32 to 0.36, all FDR-adjusted p > 0.05). There were no associations between baseline NPS and cognitive functioning over time in any clinical stage (range β = -0.13 to 0.44, all FDR-adjusted p > 0.05). DISCUSSION: NPS and cognitive symptoms are both prevalent across the AD clinical spectrum, but show a different evolution during the course of the disease.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • van den Berg, EstherErasmus University Medical Center (författare)
  • Singleton, Ellen H.Erasmus University Medical Center (författare)
  • Baart, Sara J.Erasmus University Medical Center (författare)
  • Coesmans, MichielErasmus University Medical Center (författare)
  • Leeuwis, Annebet E. (författare)
  • Teunissen, Charlotte E. (författare)
  • van Berckel, Bart N.M. (författare)
  • Pijnenburg, Yolande A.L. (författare)
  • Scheltens, Philip (författare)
  • van der Flier, Wiesje M. (författare)
  • Ossenkoppele, RikLund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Erasmus University Medical Center(Swepub:lu)ri1513os (författare)
  • Papma, Janne M. (författare)
  • Erasmus University Medical CenterKlinisk minnesforskning (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Neurology97:13, s. 1276-12871526-632X

Internetlänk

Hitta via bibliotek

  • Neurology (Sök värdpublikationen i LIBRIS)

Till lärosätets databas

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy