Interactions between cultured bovine arterial endothelial and smooth muscle cells; effects of modulated low density lipoproteins on cell proliferation and prostacyclin release

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Xu, Cang-BaoLund University,Lunds universitet,Medicin, Lund,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Medicine, Lund,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine (författare)

Interactions between cultured bovine arterial endothelial and smooth muscle cells; effects of modulated low density lipoproteins on cell proliferation and prostacyclin release

Artikel/kapitelEngelska1994

Förlag, utgivningsår, omfång ...

1994
8 s.

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LIBRIS-ID:oai:lup.lub.lu.se:fc44dc03-aae6-4a6d-a14b-b5b159f61b71
https://lup.lub.lu.se/record/fc44dc03-aae6-4a6d-a14b-b5b159f61b71URI

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Språk:engelska
Sammanfattning på:engelska

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Ämneskategori:art swepub-publicationtype
Ämneskategori:ref swepub-contenttype

Anmärkningar

We exposed bovine aortic endothelial cells in culture to native LDL (n-LDL) and LDL modulated by dimethylsulfoxide (DMSO-LDL), dimethylsulfoxide-soluble particles from cigarette smoke (DSP-LDL) or Cu2+ (Cu(2+)-LDL) to explore the hypothesis that these LDL-forms might influence interactions between endothelial and smooth muscle cells. It was shown that 3H-thymidine incorporation into endothelial cells was decreased by DMSO-LDL, DSP-LDL and Cu(2+)-LDL compared to n-LDL, while it was higher by DSP-LDL compared to its control i.e. DMSO-LDL. These effects could be transferred by conditioned medium to smooth muscle cell cultures. DSP-LDL or Cu(2+)-LDL decreased total cellular protein of endothelial cells. Initial (15 min) prostacyclin release from endothelial cells was increased by all LDL preparations compared to medium without LDL, most pronounced for Cu(2+)-LDL. If n-LDL was control, only Cu(2+)-LDL significantly increased the release of prostacyclin during 15 min and during 24 h. The release of prostacyclin assayed after 24 h was depressed by DSP-LDL compared to DMSO-LDL. This study demonstrated that interactions between endothelial and smooth muscle cells could be influenced by LDL treated by dimethylsulfoxide-soluble particles from cigarette smoke or by Cu2+, and their effects were not similar. DSP-LDL, in contrast to Cu(2+)-LDL, significantly decreased the release of prostacyclin by endothelial cells after 24 h incubations and via endothelial cell conditioned medium stimulated smooth muscle cell proliferation judged by increased 3H-thymidine incorporation. The results might be of relevance for atherogenesis.

Ämnesord och genrebeteckningar

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Neurologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Neurology hsv//eng
Animals
Cattle
Cell Division
Cells, Cultured
Copper
Dimethyl Sulfoxide
Endothelium, Vascular
Epoprostenol
Lipoproteins, LDL
Muscle, Smooth, Vascular
Plants, Toxic
Smoke
Tobacco
Journal Article
Research Support, Non-U.S. Gov't

Biuppslag (personer, institutioner, konferenser, titlar ...)

Stavenow, L. (författare)
Pessah-Rasmussen, HLund University,Lunds universitet,Rehabiliteringsmedicin,Forskargrupper vid Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Stroke policy och kvalitetsregisterforskning,Rehabilitation medicine,Lund University Research Groups,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Stroke policy and quality register research(Swepub:lu)neur-hpe (författare)
Medicin, LundSektion II (creator_code:org_t)

Sammanhörande titlar

Ingår i:Scandinavian Journal of Clinical & Laboratory Investigation54:3, s. 8-1910036-5513

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https://lup.lub.lu.se/record/fc44dc03-aae6-4a6d-a14b-b5b159f61b71

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Scandinavian Journal of Clinical & Laboratory Investigation (Sök värdpublikationen i LIBRIS)

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Av författaren/redakt...: Xu, Cang-Bao; Stavenow, L.; Pessah-Rasmussen ...

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Neurologi

Artiklar i publikationen: Scandinavian Jou ...

Av lärosätet: Lunds universitet

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