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Search: onr:"swepub:oai:lup.lub.lu.se:fc4cf98c-a54e-419c-a74b-ea4a9a2c2f5b" > Use of combined hor...

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  • Mendel, ArielleMcGill University Health Center (author)

Use of combined hormonal contraceptives among women with systemic lupus erythematosus with and without medical contraindications to oestrogen

  • Article/chapterEnglish2019

Publisher, publication year, extent ...

  • 2019-02-08
  • Oxford University Press (OUP),2019
  • 9 s.

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:fc4cf98c-a54e-419c-a74b-ea4a9a2c2f5b
  • https://lup.lub.lu.se/record/fc4cf98c-a54e-419c-a74b-ea4a9a2c2f5bURI
  • https://doi.org/10.1093/rheumatology/kez014DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:141287995URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Objectives. To assess the prevalence of combined hormonal contraceptives (CHCs) in reproductive-age women with SLE with and without possible contraindications and to determine factors associated with their use in the presence of possible contraindications. Methods. This observational cohort study included premenopausal women ages 18-45 years enrolled in the SLICC Registry ≤15 months after SLE onset, with annual assessments spanning 2000-2017. World Health Organization Category 3 or 4 contraindications to CHCs (e.g. hypertension, aPL) were assessed at each study visit. High disease activity (SLEDAI score >12 or use of >0.5 mg/kg/day of prednisone) was considered a relative contraindication. Results. A total of 927 SLE women contributed 6315 visits, of which 3811 (60%) occurred in the presence of one or more possible contraindication to CHCs. Women used CHCs during 512 (8%) visits, of which 281 (55%) took place in the setting of one or more possible contraindication. The most frequently observed contraindications were aPL (52%), hypertension (34%) and migraine with aura (22%). Women with one or more contraindication were slightly less likely to be taking CHCs [7% of visits (95% CI 7, 8)] than women with no contraindications [9% (95% CI 8, 10)]. Conclusion. CHC use was low compared with general population estimates (>35%) and more than half of CHC users had at least one possible contraindication. Many yet unmeasured factors, including patient preferences, may have contributed to these observations. Further work should also aim to clarify outcomes associated with this exposure.

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  • Bernatsky, SashaMcGill University Health Center (author)
  • Pineau, Christian A.McGill University Health Center (author)
  • St-Pierre, YvanMcGill University Health Center (author)
  • Hanly, John G.Dalhousie University (author)
  • Urowitz, Murray B.Toronto Western Hospital,University of Toronto (author)
  • Clarke, Ann E.University of Calgary (author)
  • Romero-Diaz, JuanitaInstituto Nacional de Ciencias Médicas y Nutrición (author)
  • Gordon, CarolineUniversity of Birmingham,City Hospital, Birmingham (author)
  • Bae, Sang CheolHanyang University (author)
  • Wallace, Daniel J.Cedars-Sinai Medical Center,University of California, Los Angeles (author)
  • Merrill, Joan T.Oklahoma Medical Research Foundation (author)
  • Buyon, JillNew York University (author)
  • Isenberg, David A.University College London (author)
  • Rahman, AnisurUniversity College London (author)
  • Ginzler, Ellen M.SUNY Downstate Health Sciences University (author)
  • Petri, MichelleJohns Hopkins University School of Medicine (author)
  • Dooley, Mary AnneUniversity of North Carolina (author)
  • Fortin, PaulCentre hospitalier universitaire de Québec (author)
  • Gladman, Dafna D.Toronto Western Hospital,University of Toronto (author)
  • Steinsson, KristjánNational University Hospital of Iceland (author)
  • Ramsey-Goldman, RosalindNorthwestern University Feinberg School of Medicine (author)
  • Khamashta, Munther A.University College London (author)
  • Aranow, CynthiaFeinstein Institute for Medical Research (author)
  • MacKay, MegganFeinstein Institute for Medical Research (author)
  • Alarcón, GracielaUniversity of Alabama (author)
  • Manzi, SusanAllegheny Health Network (author)
  • Nived, OlaLund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)reum-oni (author)
  • Jönsen, AndreasLund University,Lunds universitet,Lund SLE Research Group,Forskargrupper vid Lunds universitet,Lund University Research Groups(Swepub:lu)reum-ajo (author)
  • Zoma, Asad A.Hairmyres Hospital (author)
  • Van Vollenhoven, Ronald F.Karolinska Institutet,Karolinska Institute (author)
  • Ramos-Casals, ManuelHospital Clínic of Barcelona (author)
  • Ruiz-Irastorza, GiuillermoUniversity of the Basque Country (author)
  • Lim, SamEmory University (author)
  • Kalunian, Kenneth C.University of California, San Diego (author)
  • Inanc, MuratIstanbul University (author)
  • Kamen, Diane L.Medical University of South Carolina (author)
  • Peschken, Christine A.University of Manitoba (author)
  • Jacobsen, SørenCopenhagen University Hospital,University of Copenhagen (author)
  • Askanase, AncaColumbia University (author)
  • Sanchez-Guerrero, JorgeUniversity of Toronto,Mount Sinai Hospital of University of Toronto (author)
  • Bruce, Ian N.University of Manchester,Manchester University NHS Foundation Trust (author)
  • Costedoat-Chalumeau, NathalieCochin Hospital (author)
  • Vinet, EvelyneMcGill University Health Center (author)
  • McGill University Health CenterDalhousie University (creator_code:org_t)

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  • In:Rheumatology (United Kingdom): Oxford University Press (OUP)58:7, s. 1259-12671462-03241462-0332

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