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  • Bjørnsbo, Kirsten SchrollCopenhagen University Hospital (author)

Protocol for the combined cardiometabolic deep phenotyping and registry-based 20-year follow-up study of the Inter99 cohort

  • Article/chapterEnglish2024

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  • 2024

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  • LIBRIS-ID:oai:lup.lub.lu.se:fc5d2ced-e58e-48d2-bef1-e230ed9cf3dc
  • https://lup.lub.lu.se/record/fc5d2ced-e58e-48d2-bef1-e230ed9cf3dcURI
  • https://doi.org/10.1136/bmjopen-2023-078501DOI

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  • Language:English
  • Summary in:English

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  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Introduction The population-based Inter99 cohort has contributed extensively to our understanding of effects of a systematic screening and lifestyle intervention, as well as the multifactorial aetiology of type 2 diabetes (T2D) and cardiovascular disease. To understand causes, trajectories and patterns of early and overt cardiometabolic disease manifestations, we will perform a combined clinical deep phenotyping and registry follow-up study of the now 50–80 years old Inter99 participants. Methods and analysis The Inter99 cohort comprises individuals aged 30–60 years, who lived in a representative geographical area of greater Copenhagen, Denmark, in 1999. Age-stratified and sex-stratified random subgroups were invited to participate in either a lifestyle intervention (N=13 016) or questionnaires (N=5264), while the rest served as a reference population (N=43 021). Of the 13 016 individuals assigned to the lifestyle intervention group, 6784 (52%) accepted participation in a baseline health examination in 1999, including screening for cardiovascular risk factors and prediabetic conditions. In total, 6004 eligible participants, who participated in the baseline examination, will be invited to participate in the deep phenotyping 20-year follow-up clinical examination including measurements of anthropometry, blood pressure, arterial stiffness, cardiometabolic biomarkers, coronary artery calcification, heart rate variability, heart rhythm, liver stiffness, fundus characteristics, muscle strength and mass, as well as health and lifestyle questionnaires. In a subsample, 10-day monitoring of diet, physical activity and continuous glucose measurements will be performed. Fasting blood, urine and faecal samples to be stored in a biobank. The established database will form the basis of multiple analyses. A main purpose is to investigate whether low birth weight independent of genetics, lifestyle and glucose tolerance predicts later common T2D cardiometabolic comorbidities. Ethics and dissemination The study was approved by the Medical Ethics Committee, Capital Region, Denmark (H-20076231) and by the Danish Data Protection Agency through the Capital Region of Denmark’s registration system (P-2020-1074). Informed consent will be obtained before examinations. Findings will be disseminated in peer-reviewed journals, at conferences and via presentations to stakeholders, including patients and public health policymakers.

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  • Brøns, CharlotteSteno Diabetes Center Copenhagen(Swepub:lu)ch8338br (author)
  • Aadahl, MetteCopenhagen University Hospital (author)
  • Kampmann, Freja BachCopenhagen University Hospital (author)
  • Nielsen, Camilla Friis BrydeCopenhagen University Hospital (author)
  • Lundbergh, BjørnCopenhagen University Hospital (author)
  • Christensen, Rasmus WibaekSteno Diabetes Center Copenhagen (author)
  • Kårhus, Line LundCopenhagen University Hospital (author)
  • Madsen, Anja LykkeCopenhagen University Hospital (author)
  • Hansen, Christian StevnsSteno Diabetes Center Copenhagen (author)
  • Nørgaard, KirstenCopenhagen University Hospital,Steno Diabetes Center Copenhagen (author)
  • Jørgensen, Niklas RyeCopenhagen University Hospital (author)
  • Suetta, CharlotteBispebjerg Hospital (author)
  • Kjaer, MichaelBispebjerg Hospital (author)
  • Grarup, NielsNovo Nordisk Foundation Centre for Basic Metabolic Research (author)
  • Kanters, JørgenNovo Nordisk Foundation Centre for Basic Metabolic Research,University of California, San Francisco (author)
  • Larsen, MichaelCopenhagen University Hospital (author)
  • Køber, LarsCopenhagen University Hospital (author)
  • Kofoed, Klaus FuglsangCopenhagen University Hospital (author)
  • Loos, RuthNovo Nordisk Foundation Centre for Basic Metabolic Research (author)
  • Hansen, TorbenNovo Nordisk Foundation Centre for Basic Metabolic Research (author)
  • Linneberg, AllanCopenhagen University Hospital (author)
  • Vaag, AllanLund University,Lunds universitet,Translationell diabetesforskning,Forskargrupper vid Lunds universitet,Translational Diabetes Research,Lund University Research Groups,Skåne University Hospital,Steno Diabetes Center Copenhagen(Swepub:lu)med-ava (author)
  • Copenhagen University HospitalSteno Diabetes Center Copenhagen (creator_code:org_t)

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  • In:BMJ Open14:12044-6055

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