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Heterogeneity of is...
Heterogeneity of islet pathology in two infants with recent onset diabetes mellitus
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- Lernmark, Å (author)
- University of Washington, Seattle
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- Stenger, D. (author)
- University of Washington, Seattle
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- Baskin, D. G. (author)
- University of Washington, Seattle
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- Palmer, J. P. (author)
- University of Washington, Seattle
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- Li, L. (author)
- University of Washington, Seattle
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- Klöppel, G. (author)
- Vrije Universiteit Brussel (VUB)
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- Vathanaprida, C. (author)
- Veterans Health Administration
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- Fält, K. (author)
- Skåne University Hospital
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- Landin-Olsson, M. (author)
- Lund University,Lunds universitet,Medicin/akutsjukvård, Lund,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Medicine, Lund,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Gown, A. M. (author)
- University of Washington, Seattle
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- Petersen, J. S. (author)
- Hagedorn Research Institute
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- Edenvall, H. (author)
- Blekinge Hospital
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- Mauseth, R. S. (author)
- University of Washington, Seattle
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(creator_code:org_t)
- 1995
- 1995
- English 10 s.
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In: Virchows Archiv. - 0945-6317. ; 425:6, s. 631-640
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http://dx.doi.org/10...
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Abstract
Subject headings
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- The mechanisms by which the beta cells of pancreatic islets are destroyed in insulin-dependent diabetes mellitus (IDDM) are poorly understood. In this report the pancreatic histo- and immunopathology of two children, both HLA-DR 3/4, DQ 2/8 positive and who both died from cerebral oedema within a day of clinical diagnosis of IDDM, were investigated. Patient 1, a 14-month-old girl, had a 4-week history of polydipsia and polyuria. Patient 2, a 3-year-old boy, had 2 days of illness. Both patients had a similarly severe loss of insulin cells but differed markedly as to the extent of lymphocytic islet infiltration (insulitis). Apart from insulitis, marked islet macrophage infiltration was demonstrated in both patients with the HAM-56 monoclonal antibody. Neither patient showed aberrant expression of HLA class II antigens on insulin-immunoreactive cells, but allele-specific HLA-DQ8 expression was evident on endothelial cells. Glutamic acid decarboxylase immunoreactivity was detected in both insulin- and glucagon-immunoreactive cells. It is concluded that the heterogeneity of islet pathology, especially insulitis, may reflect different dynamics and extent rather than different pathomechanisms of immune destruction of islets in IDDM.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Keyword
- Glutamic acid decarboxylase
- Insulitis
- Islet cell macrophages
- Islet destruction
- Recent-onset insulin dependent diabetes mellitus
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Lernmark, Å
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Stenger, D.
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Baskin, D. G.
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Palmer, J. P.
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Li, L.
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Klöppel, G.
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show more...
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Vathanaprida, C.
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Fält, K.
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Landin-Olsson, M ...
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Gown, A. M.
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Petersen, J. S.
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Edenvall, H.
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Mauseth, R. S.
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
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Virchows Archiv
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Lund University