Chromosomal translocations and leukaemia : a role for LMO2 in T cell acute leukaemia, in transcription and in erythropoiesis

• The LMO2 gene associated with T cell acute leukaemia has been used as an example of a gene activated by association with the T cell receptor genes after chromosomal translocations. The gene is shown to encode a LIM protein which is involved in protein interactions and during normal haematopoiesis is necessary for erythroid development. LMO2 has been shown to cause tumours when aberrantly expressed and to be able to heterodimerise with TAL1 to facilitate tumour development.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Hematologi (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Hematology (hsv//eng)

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Medical Genetics (hsv//eng)

Keyword

Adaptor Proteins, Signal Transducing

Animals

Chromosomes, Human, Pair 11

DNA-Binding Proteins

Erythropoiesis

Hematopoiesis

Humans

LIM Domain Proteins

Leukemia-Lymphoma, Adult T-Cell

Metalloproteins

Mice

Mice, Transgenic

Proto-Oncogene Proteins

Proto-Oncogenes

Transcription, Genetic

Translocation, Genetic

Publication and Content Type

art (subject category)

ref (subject category)