Tumors with non-functional RB1 are killed by reduced gamma-tubulin levels.

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Ehlén, ÅsaLund University,Lunds universitet,Patologi, Malmö,Forskargrupper vid Lunds universitet,Pathology, Malmö,Lund University Research Groups (author)

Tumors with non-functional RB1 are killed by reduced gamma-tubulin levels.

Article/chapterEnglish2012

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2012

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LIBRIS-ID:oai:lup.lub.lu.se:fc9841d0-9d91-4af3-bd7a-5c6e365fd551
https://lup.lub.lu.se/record/2519610URI
https://doi.org/10.1074/jbc.M112.357038DOI

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Language:English
Summary in:English

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In various tumors inactivation of growth control is achieved by interfering with the RB1 signaling pathway. Here, we describe that RB1 and γ tubulin proteins moderate each other's expression by binding to their respective gene promoters. Simultaneous reduction of RB1 and γ tubulin protein levels result in an E2F1-dependent upregulation of apoptotic genes such as caspase 3. We report that in various tumors types, there is an inverse correlation between the expression levels of γ tubulin and RB1 and that in tumor cell lines with a non-functioning RB1, reduction of γ tubulin protein levels leads to induction of apoptosis. Thus, the RB1/γ tubulin signal network can be considered as a new target for cancer treatment.

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Rossello Castillo, Catalina AnaLund University,Lunds universitet,Patologi, Malmö,Forskargrupper vid Lunds universitet,Pathology, Malmö,Lund University Research Groups(Swepub:lu)med-crc (author)
von Stedingk, KristofferLund University,Lunds universitet,Institutionen för translationell medicin,Medicinska fakulteten,Department of Translational Medicine,Faculty of Medicine(Swepub:lu)med-kvt (author)
Eklund, GretaLund University,Lunds universitet,Patologi, Malmö,Forskargrupper vid Lunds universitet,Pathology, Malmö,Lund University Research Groups(Swepub:lu)med-geh (author)
Nilsson, EliseLund University,Lunds universitet,Patologi, Malmö,Forskargrupper vid Lunds universitet,Pathology, Malmö,Lund University Research Groups(Swepub:lu)pat-eni (author)
Pettersson, HelenLund University,Lunds universitet,Institutionen för translationell medicin,Medicinska fakulteten,Department of Translational Medicine,Faculty of Medicine(Swepub:lu)molm-hpe (author)
Jirström, KarinLund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)pat-kji (author)
Alvarado-Kristensson, MariaLund University,Lunds universitet,Molekylär patologi, Malmö,Forskargrupper vid Lunds universitet,Patologi, Malmö,Molecular Pathology, Malmö,Lund University Research Groups,Pathology, Malmö(Swepub:lu)expp-mkr (author)
Patologi, MalmöForskargrupper vid Lunds universitet (creator_code:org_t)

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In:Journal of Biological Chemistry287:21, s. 17241-172471083-351X

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Cell and Molecul ...

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