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Long-term survival ...
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Gelder, Marion E Meijer-VanYukioka Hospital
(author)
Long-term survival of patients with CLL after allogeneic transplantation : A report from the European Society for Blood and Marrow Transplantation
- Article/chapterEnglish2017
Publisher, publication year, extent ...
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2016-12-12
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Springer Science and Business Media LLC,2017
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9 s.
Numbers
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LIBRIS-ID:oai:lup.lub.lu.se:fcc5c1f4-5f0d-416e-8e9b-9719ff9a7d87
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https://lup.lub.lu.se/record/fcc5c1f4-5f0d-416e-8e9b-9719ff9a7d87URI
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https://doi.org/10.1038/bmt.2016.282DOI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:art swepub-publicationtype
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Subject category:ref swepub-contenttype
Notes
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Even with the availability of targeted drugs, allogeneic hematopoietic cell transplantation (allo-HCT) is the only therapy with curative potential for patients with CLL. Cure can be assessed by comparing long-term survival of patients to the matched general population. Using data from 2589 patients who received allo-HCT between 2000 and 2010, we used landmark analyses and methods from relative survival analysis to calculate excess mortality compared with an age-, sex- and calendar year-matched general population. Estimated event-free survival, overall survival and non-relapse mortality (NRM) 10 years after allo-HCT were 28% (95% confidence interval (CI), 25-31), 35% (95% CI, 32-38) and 40% (95% CI, 37-42), respectively. Patients who passed the 5-year landmark event-free survival (N=394) had a 79% probability (95% CI, 73-85) of surviving the subsequent 5 years without an event. Relapse and NRM contributed equally to treatment failure. Five-year mortality for 45- and 65-year-old reference patients who were event-free at the 5-year landmark was 8% and 47% compared with 3% and 14% in the matched general population, respectively. The prospect of long-term disease-free survival remains an argument to consider allo-HCT for young patients with high-risk CLL, and programs to understand and prevent late causes of failure for long-term survivors are warranted, especially for older patients.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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De Wreede, L. C.Leiden University Medical Centre,DKMS gemeinnützige GmbH
(author)
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Bornhäuser, M.Medizinsche Klinik und Poliklinik I, Dresden
(author)
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Niederwieser, DUniversity Hospital Leipzig
(author)
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Karas, M.University Hospital in Pilsen
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Anderson, N. S.Copenhagen University Hospital
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Gramatzki, MartinUniversity Medical Center Schleswig-Holstein
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Dreger, P.Heidelberg University
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Michallet, MauricetteCentre Hospitalier Lyon Sud
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Petersen, Bo EUniversity Medical Center Utrecht
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Bunjes, D.University Hospital of Ulm
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Potter, Michael NRoyal Marsden Hospital, London
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Beelen, D.University Hospital Essen
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Cornelissen, Jan JErasmus University Medical Center
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Yakoub-Agha, I.Lille University Hospital
(author)
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Russell, Nigel HNottingham City Hospital
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Finke, J.Albert-Ludwigs University Freiburg
(author)
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Schoemans, H.University Hospitals Leuven
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Vitek, AInstitute of Hematology and Blood Transfusion, Prauge
(author)
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Blaise, D.Institut Paoli-Calmettes
(author)
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Volin, LHelsinki University Central Hospital
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Chevallier, PatriceNantes University Hospital
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Caballero, DoloresUniversity Hospital of Salamanca
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Putter, H.Leiden University Medical Centre
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van Biezen, AnjaLeiden University Medical Centre
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Henseler, A.Leiden University Medical Centre
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Schönland, S OHeidelberg University
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Kröger, NicolausUniversity Medical Center Hamburg-Eppendorf
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Schetelig, J.Medizinsche Klinik und Poliklinik I, Dresden,DKMS gemeinnützige GmbH
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Ehninger, GerhardMedizinsche Klinik und Poliklinik I, Dresden
(author)
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Niederwieser, DietgerUniversity Hospital Leipzig
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Jindra, PavelUniversity Hospital in Pilsen
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Sengeloev, HenrikCopenhagen University Hospital
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Gramatzki, MartinUniversity Medical Center Schleswig-Holstein
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Dreger, PeterHeidelberg University
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Petersen, EefkeUniversity Medical Center Utrecht
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Bunjes, DonaldUniversity Hospital of Ulm
(author)
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Potter, Michael NRoyal Marsden Hospital, London
(author)
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Beelen, DietrichUniversity Hospital Essen
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Cornelissen, JanErasmus University Medical Center
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Yakoub-Agha, IbrahimLille University Hospital
(author)
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Russell, NigelNottingham City Hospital
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Finke, JürgenAlbert-Ludwigs University Freiburg
(author)
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Schoemans, HélèneUniversity Hospitals Leuven
(author)
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Vitek, AntoninInstitute of Hematology and Blood Transfusion, Prauge
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Ispizua, Alvaro UrbanoHospital Clínic of Barcelona
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Blaise, DidierInstitut Paoli-Calmettes
(author)
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Lenhoff, StigLund University,Lunds universitet,Avdelningen för hematologi och transfusionsmedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Hematology and Transfusion Medicine,Department of Laboratory Medicine,Faculty of Medicine,Skåne University Hospital(Swepub:lu)med-slf
(author)
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Solano, CarlosUniversity and Polytechnic Hospital la Fe(Swepub:lu)chem-cso
(author)
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Yukioka HospitalLeiden University Medical Centre
(creator_code:org_t)
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Chronic Malignancy Working Party
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In:Bone Marrow Transplantation: Springer Science and Business Media LLC52:3, s. 372-3800268-33691476-5365
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Gelder, Marion E ...
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De Wreede, L. C.
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Bornhäuser, M.
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Niederwieser, D
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Karas, M.
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Anderson, N. S.
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Gramatzki, Marti ...
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Dreger, P.
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Michallet, Mauri ...
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Petersen, Bo E
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Bunjes, D.
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Potter, Michael ...
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Beelen, D.
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Cornelissen, Jan ...
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Yakoub-Agha, I.
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Russell, Nigel H
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Finke, J.
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Schoemans, H.
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Vitek, A
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Blaise, D.
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Volin, L
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Chevallier, Patr ...
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Caballero, Dolor ...
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Putter, H.
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van Biezen, Anja
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Henseler, A.
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Schönland, S O
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Kröger, Nicolaus
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Schetelig, J.
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Ehninger, Gerhar ...
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Niederwieser, Di ...
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Jindra, Pavel
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Sengeloev, Henri ...
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Dreger, Peter
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Petersen, Eefke
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Bunjes, Donald
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Beelen, Dietrich
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Cornelissen, Jan
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Yakoub-Agha, Ibr ...
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Russell, Nigel
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Finke, Jürgen
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Schoemans, Hélèn ...
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Vitek, Antonin
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Ispizua, Alvaro ...
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Blaise, Didier
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Lenhoff, Stig
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Solano, Carlos
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and Hematology
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