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The molecular genet...
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Seidlitz, JakobUniversity of Pennsylvania,The Children's Hospital of Philadelphia
(författare)
The molecular genetic landscape of human brain size variation
- Artikel/kapitelEngelska2023
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Nummerbeteckningar
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LIBRIS-ID:oai:lup.lub.lu.se:fd63c7ba-822e-4722-a349-d065e7f7097c
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https://lup.lub.lu.se/record/fd63c7ba-822e-4722-a349-d065e7f7097cURI
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https://doi.org/10.1016/j.celrep.2023.113439DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:art swepub-publicationtype
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Human brain size changes dynamically through early development, peaks in adolescence, and varies up to 2-fold among adults. However, the molecular genetic underpinnings of interindividual variation in brain size remain unknown. Here, we leveraged postmortem brain RNA sequencing and measurements of brain weight (BW) in 2,531 individuals across three independent datasets to identify 928 genome-wide significant associations with BW. Genes associated with higher or lower BW showed distinct neurodevelopmental trajectories and spatial patterns that mapped onto functional and cellular axes of brain organization. Expression of BW genes was predictive of interspecies differences in brain size, and bioinformatic annotation revealed enrichment for neurogenesis and cell-cell communication. Genome-wide, transcriptome-wide, and phenome-wide association analyses linked BW gene sets to neuroimaging measurements of brain size and brain-related clinical traits. Cumulatively, these results represent a major step toward delineating the molecular pathways underlying human brain size variation in health and disease.
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Biuppslag (personer, institutioner, konferenser, titlar ...)
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Mallard, Travis T.Massachusetts General Hospital,Harvard Medical School,Broad Institute
(författare)
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Vogel, Jacob W.University of Pennsylvania(Swepub:lu)ja8870vo
(författare)
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Lee, Younga H.Broad Institute,Harvard Medical School,Massachusetts General Hospital
(författare)
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Warrier, VarunUniversity of Cambridge
(författare)
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Ball, GarethMurdoch Children's Research Institute,University of Melbourne
(författare)
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Hansson, OskarLund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,LU profilområde: Proaktivt åldrande,Lunds universitets profilområden,Clinical Memory Research,Lund University Research Groups,LU Profile Area: Proactive Ageing,Lund University Profile areas,Skåne University Hospital: Memory Clinic (MemoryHealth),Skåne University Hospital(Swepub:lu)mphy-ohn
(författare)
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Hernandez, Leanna M.University of California, Los Angeles
(författare)
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Mandal, Ayan S.University of Pennsylvania,The Children's Hospital of Philadelphia
(författare)
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Wagstyl, KonradWellcome Trust Centre for Neuroimaging, London
(författare)
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Lombardo, Michael V.Italian Institute of Technology
(författare)
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Courchesne, EricUniversity of California, San Diego
(författare)
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Glessner, Joseph T.The Children's Hospital of Philadelphia,University of Pennsylvania
(författare)
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Satterthwaite, Theodore D.The Children's Hospital of Philadelphia,University of Pennsylvania
(författare)
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Bethlehem, Richard A.I.University of Cambridge
(författare)
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Bernstock, Joshua D.Massachusetts Institute of Technology,Harvard University
(författare)
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Tasaki, ShinyaRush Alzheimer's Disease Center
(författare)
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Ng, BernardRush Alzheimer's Disease Center
(författare)
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Gaiteri, ChrisRush Alzheimer's Disease Center
(författare)
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Smoller, Jordan W.Massachusetts General Hospital,Harvard Medical School,Broad Institute
(författare)
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Ge, TianBroad Institute,Harvard Medical School,Massachusetts General Hospital
(författare)
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Gur, Raquel E.The Children's Hospital of Philadelphia,University of Pennsylvania
(författare)
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Gandal, Michael J.University of Pennsylvania,The Children's Hospital of Philadelphia
(författare)
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Alexander-Bloch, A. F.The Children's Hospital of Philadelphia,University of Pennsylvania
(författare)
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University of PennsylvaniaThe Children's Hospital of Philadelphia
(creator_code:org_t)
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Lifespan Brain Chart Consortium
Sammanhörande titlar
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Ingår i:Cell Reports42:112211-1247
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Seidlitz, Jakob
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Mallard, Travis ...
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Vogel, Jacob W.
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Lee, Younga H.
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Warrier, Varun
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Ball, Gareth
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Hansson, Oskar
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Hernandez, Leann ...
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Mandal, Ayan S.
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Wagstyl, Konrad
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Lombardo, Michae ...
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Courchesne, Eric
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Glessner, Joseph ...
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Satterthwaite, T ...
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Bethlehem, Richa ...
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Bernstock, Joshu ...
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Tasaki, Shinya
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Ng, Bernard
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Gaiteri, Chris
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Smoller, Jordan ...
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Ge, Tian
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Gur, Raquel E.
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Gandal, Michael ...
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Alexander-Bloch, ...
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