WFRF:(Winkleby Marilyn A.)
Search: WFRF:(Winkleby Marilyn A.) > Perinatal And Famil...
- 21 of 33
- Previous record
- Next record
- To hitlist
- Crump, CaseyStanford University (author)
Perinatal And Familial Risk Factors For Brain Tumors in Childhood Through Young Adulthood.
- Article/chapterEnglish2015
Publisher, publication year, extent ...
- 2015
Numbers
- LIBRIS-ID:oai:lup.lub.lu.se:fd8fb8d8-f4c9-41ac-ad74-532e413bcf30
- https://lup.lub.lu.se/record/4908196URI
- https://doi.org/10.1158/0008-5472.CAN-14-2285DOI
Supplementary language notes
- Language:English
- Summary in:English
Part of subdatabase
- SwePubSwePub
Classification
Notes
- Perinatal factors including high birth weight have been associated with childhood brain tumors in case-control studies. However, the specific contributions of gestational age and fetal growth remain unknown, and these issues have never been examined in large cohort studies with follow-up into adulthood. We conducted a national cohort study of 3,571,574 persons born in Sweden in 1973-2008, followed up for brain tumor incidence through 2010 (maximum age 38 years) to examine perinatal and familial risk factors. There were 2,809 brain tumors in 69.7 million person-years of follow-up. After adjusting for potential confounders, significant risk factors for brain tumors included high fetal growth (incidence rate ratio [IRR] per additional 1 standard deviation, 1.04; 95% CI, 1.01-1.08, P=0.02), first-degree family history of a brain tumor (IRR, 2.43; 95% CI, 1.86-3.18, P<0.001), parental country of birth (IRR for both parents born in Sweden vs. other countries, 1.21; 95% CI, 1.09-1.35, P<0.001), and high maternal education level (Ptrend=0.01). These risk factors did not vary by age at diagnosis. The association with high fetal growth appeared to involve pilocytic astrocytomas, but not other astrocytomas, medulloblastomas, or ependymomas. Gestational age at birth, birth order, multiple birth, and parental age were not associated with brain tumors. In this large cohort study, high fetal growth was associated with an increased risk of brain tumors (particularly pilocytic astrocytomas) independently of gestational age, not only in childhood but also into young adulthood, suggesting that growth factor pathways may play an important long-term role in the etiology of certain brain tumor subtypes.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
- Sundquist, JanLund University,Lunds universitet,Allmänmedicin och klinisk epidemiologi,Forskargrupper vid Lunds universitet,Family Medicine and Clinical Epidemiology,Lund University Research Groups,Stanford University(Swepub:lu)med-jsu (author)
- Sieh, WeivaStanford University (author)
- Winkleby, Marilyn AStanford University (author)
- Sundquist, KristinaLund University,Lunds universitet,Allmänmedicin och klinisk epidemiologi,Forskargrupper vid Lunds universitet,Family Medicine and Clinical Epidemiology,Lund University Research Groups,Stanford University(Swepub:lu)med-ksq (author)
- Stanford UniversityAllmänmedicin och klinisk epidemiologi (creator_code:org_t)
Related titles
- In:Cancer Research75:3, s. 576-5831538-7445
Internet link
Find in a library
- Cancer Research (Search for host publication in LIBRIS)
To the university's database
- 21 of 33
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Crump, Casey
- Sundquist, Jan
- Sieh, Weiva
- Winkleby, Marily ...
- Sundquist, Krist ...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Clinical Medicin ...
- and Cancer and Oncol ...
- Articles in the publication
- Cancer Research
- By the university
- Lund University
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
