The effect of a randomised controlled lifestyle intervention on weight loss and plasma proneurotensin

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Bennet, LouiseLund University,Lunds universitet,Allmänmedicin och samhällsmedicin,Forskargrupper vid Lunds universitet,Family Medicine and Community Medicine,Lund University Research Groups,Skåne University Hospital,Clinical Studies Sweden-Forum South (författare)

The effect of a randomised controlled lifestyle intervention on weight loss and plasma proneurotensin

Artikel/kapitelEngelska2022

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2022-10-31
Springer Science and Business Media LLC,2022

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LIBRIS-ID:oai:lup.lub.lu.se:fdc4e357-73aa-4e96-9276-7986bbc76234
https://lup.lub.lu.se/record/fdc4e357-73aa-4e96-9276-7986bbc76234URI
https://doi.org/10.1186/s12902-022-01183-4DOI

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Språk:engelska
Sammanfattning på:engelska

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AIMS: Proneurotensin (Pro-NT) is a strong predictor of cardiometabolic disease including type 2 diabetes and obesity, however, the effect of lifestyle change on Pro-NT has not been investigated in this context. Middle Eastern (ME) immigrants represent the largest and fastest growing minority population in Europe and are a high-risk population for obesity and type 2 diabetes. In this randomised controlled lifestyle intervention (RCT) addressing ME immigrants to Sweden where weight-loss was previously studied as the main outcome, as a secondary analysis we aimed to study change in Pro-NT during follow-up and if baseline Pro-NT predicted weight loss.METHODS: Immigrants from the Middle East at high risk for type 2 diabetes were invited to participate in this RCT adapted lifestyle intervention of four months' duration. The intervention group (N = 48) received a culturally adapted lifestyle intervention comprising seven group sessions and a cooking class addressing healthier diet and increased physical activity. The control group (N = 44) received treatment as usual with information to improve lifestyle habits on their own. Data assessed using mixed effects regression.OUTCOMES: Primary outcome; change in Pro-NT. Secondary outcome; change in BMI in relation to baseline plasma concentration of Pro-NT.RESULTS: During the four months follow up, weight was significantly reduced in the intervention (-2.5 kg) compared to the control group (0.8 kg) (β -0.12, 95% CI -0.24 to -0.01, P = 0.028). Pro-NT increased to a significantly greater extent in the intervention compared to the control group during follow up (28.2 vs. 3.5 pmol/L) (β 11.4; 4.8 to 18.02, P < 0.001). Change over time in BMI was associated with baseline Pro-NT (β 0.02; 0.01 to 0.04, P = 0.041).CONCLUSION: In consistence with data from surgical weight loss, this RCT paradoxically shows increased levels of Pro-NT during a multifactorial lifestyle intervention resulting in weight loss. Long term studies of Pro-NT following weight loss are needed.TRIAL REGISTRATION: This study is a secondary analysis of the RCT trial registered at www.CLINICALTRIALS.gov . REGISTRATION NUMBER: NCT01420198. Date of registration 19/08/2011. The performance and results of this trial conform to the CONSORT 2010 guidelines.

Ämnesord och genrebeteckningar

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Endokrinologi och diabetes hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Endocrinology and Diabetes hsv//eng
Humans
Diabetes Mellitus, Type 2/complications
Exercise
Life Style
Weight Loss
Obesity/therapy

Biuppslag (personer, institutioner, konferenser, titlar ...)

Fawad, AyeshaLund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups,Region Skåne(Swepub:lu)med-ayf (författare)
Struck, JoachimSphingotec GmbH (författare)
Larsson, Sara LönnLund University,Lunds universitet,Allmänmedicin och klinisk epidemiologi,Forskargrupper vid Lunds universitet,Family Medicine and Clinical Epidemiology,Lund University Research Groups,Skåne University Hospital,Clinical Studies Sweden-Forum South(Swepub:lu)mats-sla (författare)
Bergmann, AndreasSphingotec GmbH (författare)
Melander, OlleLund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups,Skåne University Hospital,Region Skåne(Swepub:lu)endo-ome (författare)
Allmänmedicin och samhällsmedicinForskargrupper vid Lunds universitet (creator_code:org_t)

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Ingår i:BMC Endocrine Disorders: Springer Science and Business Media LLC22:11472-6823

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Av författaren/redakt...: Bennet, Louise; Fawad, Ayesha; Struck, Joachim; Larsson, Sara Lö ...; Bergmann, Andrea ...; Melander, Olle

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Endokrinologi oc ...

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