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Development of a no...
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Richards, Cathy E.Beaumont Hospital, Dublin
(författare)
Development of a novel weighted ranking method for immunohistochemical quantification of a heterogeneously expressed protein in gastro-esophageal cancers
- Artikel/kapitelEngelska2021
Förlag, utgivningsår, omfång ...
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2021-03-13
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MDPI AG,2021
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12 s.
Nummerbeteckningar
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LIBRIS-ID:oai:lup.lub.lu.se:fe1c78fc-d355-4f8c-9b15-91fb9c2c5b26
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https://lup.lub.lu.se/record/fe1c78fc-d355-4f8c-9b15-91fb9c2c5b26URI
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https://doi.org/10.3390/cancers13061286DOI
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Språk:engelska
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Sammanfattning på:engelska
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Klassifikation
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Ämneskategori:art swepub-publicationtype
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Ämneskategori:ref swepub-contenttype
Anmärkningar
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High expression of Junctional Adhesion Molecule-A (JAM-A) has been linked with poor prognosis in several cancers, including breast cancers overexpressing the human epidermal growth factor receptor-2 (HER2). Furthermore, JAM-A expression has been linked with regulating that of HER2, and associated with the development of resistance to HER2-targeted therapies in breast cancer patients. The purpose of this study was to establish a potential relationship between JAM-A and HER2 in HER2-overexpressing gastro-esophageal (GE) cancers. Interrogation of gene expression datasets revealed that high JAM-A mRNA expression was associated with poorer survival in HER2-positive gastric cancer patients. However, high intra-tumoral heterogeneity of JAM-A protein expression was noted upon immunohistochemical scoring of a GE cancer tissue microarray (TMA), precluding a simple confirmation of any relationship between JAM-A and HER2 at protein level. However, in a test-set of 25 full-face GE cancer tissue sections, a novel weighted ranking system proved effective in capturing JAM-A intra-tumoral heterogeneity and confirming statistically sig-nificant correlations between JAM-A/HER2 expression. Given the growing importance of immuno-histochemistry in stratifying cancer patients for the receipt of new targeted therapies, this may sound a cautionary note against over-relying on cancer TMAs in biomarker discovery studies of heterogeneously expressed proteins. It also highlights a timely need to develop validated mechanisms of capturing intra-tumoral heterogeneity to aid in future biomarker/therapeutic target development for the benefit of cancer patients.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Sheehan, Katherine M.Beaumont Hospital, Dublin
(författare)
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Kay, Elaine W.Beaumont Hospital, Dublin
(författare)
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Hedner, CharlottaLund University,Lunds universitet,Terapeutisk patologi,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Therapeutic pathology,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,LUCC: Lund University Cancer Centre,Other Strong Research Environments(Swepub:lu)med-cah
(författare)
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Borg, DavidLund University,Lunds universitet,Terapeutisk patologi,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Therapeutic pathology,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,LUCC: Lund University Cancer Centre,Other Strong Research Environments(Swepub:lu)onk-dbo
(författare)
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Fay, JoannaBeaumont Hospital, Dublin
(författare)
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O’grady, AnthonyBeaumont Hospital, Dublin
(författare)
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Hill, Arnold D.K.Beaumont Hospital, Dublin
(författare)
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Jirström, KarinLund University,Lunds universitet,Terapeutisk patologi,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Therapeutic pathology,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,LUCC: Lund University Cancer Centre,Other Strong Research Environments(Swepub:lu)pat-kji
(författare)
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Hopkins, Ann M.Beaumont Hospital, Dublin
(författare)
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Beaumont Hospital, DublinTerapeutisk patologi
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Cancers: MDPI AG13:62072-6694
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Cancers
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Richards, Cathy ...
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Sheehan, Katheri ...
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Kay, Elaine W.
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Hedner, Charlott ...
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Borg, David
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Fay, Joanna
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visa fler...
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O’grady, Anthony
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Hill, Arnold D.K ...
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Jirström, Karin
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Hopkins, Ann M.
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Cancer och onkol ...
- Artiklar i publikationen
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Cancers
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Lunds universitet