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A variant in FTO sh...
A variant in FTO shows association with melanoma risk not due to BMI
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Iles, Mark M. (author)
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Law, Matthew H. (author)
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Stacey, Simon N. (author)
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show more...
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Han, Jiali (author)
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Fang, Shenying (author)
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Pfeiffer, Ruth (author)
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Harland, Mark (author)
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MacGregor, Stuart (author)
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Taylor, John C. (author)
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Aben, Katja K. (author)
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Akslen, Lars A. (author)
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Avril, Marie-Francoise (author)
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Azizi, Esther (author)
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Bakker, Bert (author)
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Benediktsdottir, Kristrun R. (author)
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Bergman, Wilma (author)
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Scarra, Giovanna Bianchi (author)
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Brown, Kevin M. (author)
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Calista, Donato (author)
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Chaudru, Valerie (author)
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Fargnoli, Maria Concetta (author)
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Cust, Anne E. (author)
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Demenais, Florence (author)
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Waal, Anne C. de (author)
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Debniak, Tadeusz (author)
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Elder, David E. (author)
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Friedman, Eitan (author)
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Galan, Pilar (author)
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Ghiorzo, Paola (author)
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Gillanders, Elizabeth M. (author)
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Goldstein, Alisa M. (author)
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Gruis, Nelleke A. (author)
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- Hansson, Johan (author)
- Karolinska Institutet
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Helsing, Per (author)
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Hocevar, Marko (author)
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- Hoiom, Veronica (author)
- Karolinska Institutet
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Hopper, John L. (author)
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- Ingvar, Christian (author)
- Lund University,Lunds universitet,Kirurgi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Surgery (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine
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Janssen, Marjolein (author)
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Jenkins, Mark A. (author)
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Kanetsky, Peter A. (author)
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Kiemeney, Lambertus A. (author)
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Lang, Julie (author)
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Lathrop, G. Mark (author)
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Leachman, Sancy (author)
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Lee, Jeffrey E. (author)
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Lubinski, Jan (author)
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Mackie, Rona M. (author)
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Mann, Graham J. (author)
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Martin, Nicholas G. (author)
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Mayordomo, Jose I. (author)
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Molven, Anders (author)
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Mulder, Suzanne (author)
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Nagore, Eduardo (author)
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Novakovic, Srdjan (author)
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Okamoto, Ichiro (author)
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Olafsson, Jon H. (author)
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- Olsson, Håkan (author)
- Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine
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Pehamberger, Hubert (author)
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Peris, Ketty (author)
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Grasa, Maria Pilar (author)
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Planelles, Dolores (author)
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Puig, Susana (author)
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Puig-Butille, Joan Anton (author)
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Randerson-Moor, Juliette (author)
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Requena, Celia (author)
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Rivoltini, Licia (author)
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Rodolfo, Monica (author)
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Santinami, Mario (author)
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Sigurgeirsson, Bardur (author)
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Snowden, Helen (author)
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Song, Fengju (author)
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Sulem, Patrick (author)
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Thorisdottir, Kristin (author)
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- Tuominen, Rainer (author)
- Karolinska Institutet
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Van Belle, Patricia (author)
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van der Stoep, Nienke (author)
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van Rossum, Michelle M. (author)
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Wei, Qingyi (author)
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Wendt, Judith (author)
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Zelenika, Diana (author)
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Zhang, Mingfeng (author)
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Landi, Maria Teresa (author)
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Thorleifsson, Gudrnar (author)
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Bishop, D. Timothy (author)
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Amos, Christopher I. (author)
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Hayward, Nicholas K. (author)
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Stefansson, Kari (author)
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Bishop, Julia A. Newton (author)
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Barrett, Jennifer H. (author)
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(creator_code:org_t)
- 2013-03-03
- 2013
- English.
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In: Nature Genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 45:4, s. 428-432
- Related links:
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http://dx.doi.org/10...
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https://europepmc.or...
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Abstract
Subject headings
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- We report the results of an association study of melanoma that is based on the genome-wide imputation of the genotypes of 1,353 cases and 3,566 controls of European origin conducted by the GenoMEL consortium. This revealed an association between several SNPs in intron 8 of the FTO gene, including rs16953002, which replicated using 12,313 cases and 55,667 controls of European ancestry from Europe, the USA and Australia (combined P = 3.6 x 10(-12), per-allele odds ratio for allele A = 1.16). In addition to identifying a new melanomasusceptibility locus, this is to our knowledge the first study to identify and replicate an association with SNPs in FTO not related to body mass index (BMI). These SNPs are not in intron 1 (the BMI-related region) and exhibit no association with BMI. This suggests FTO's function may be broader than the existing paradigm that FTO variants influence multiple traits only through their associations with BMI and obesity.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Iles, Mark M.
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Law, Matthew H.
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Stacey, Simon N.
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Han, Jiali
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Fang, Shenying
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Pfeiffer, Ruth
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show more...
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Harland, Mark
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MacGregor, Stuar ...
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Taylor, John C.
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Aben, Katja K.
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Akslen, Lars A.
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Avril, Marie-Fra ...
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Azizi, Esther
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Bakker, Bert
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Benediktsdottir, ...
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Bergman, Wilma
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Scarra, Giovanna ...
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Brown, Kevin M.
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Calista, Donato
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Chaudru, Valerie
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Fargnoli, Maria ...
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Cust, Anne E.
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Demenais, Floren ...
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Waal, Anne C. de
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Debniak, Tadeusz
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Elder, David E.
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Friedman, Eitan
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Galan, Pilar
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Ghiorzo, Paola
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Gillanders, Eliz ...
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Goldstein, Alisa ...
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Gruis, Nelleke A ...
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Hansson, Johan
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Helsing, Per
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Hocevar, Marko
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Hoiom, Veronica
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Hopper, John L.
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Ingvar, Christia ...
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Janssen, Marjole ...
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Jenkins, Mark A.
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Kanetsky, Peter ...
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Kiemeney, Lamber ...
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Lang, Julie
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Lathrop, G. Mark
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Leachman, Sancy
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Lee, Jeffrey E.
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Lubinski, Jan
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Mackie, Rona M.
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Mann, Graham J.
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Martin, Nicholas ...
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Mayordomo, Jose ...
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Molven, Anders
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Mulder, Suzanne
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Nagore, Eduardo
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Novakovic, Srdja ...
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Okamoto, Ichiro
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Olafsson, Jon H.
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Olsson, Håkan
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Pehamberger, Hub ...
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Peris, Ketty
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Grasa, Maria Pil ...
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Planelles, Dolor ...
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Puig, Susana
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Puig-Butille, Jo ...
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Randerson-Moor, ...
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Requena, Celia
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Rivoltini, Licia
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Rodolfo, Monica
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Santinami, Mario
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Sigurgeirsson, B ...
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Snowden, Helen
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Song, Fengju
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Sulem, Patrick
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Thorisdottir, Kr ...
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Tuominen, Rainer
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Van Belle, Patri ...
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van der Stoep, N ...
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van Rossum, Mich ...
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Wei, Qingyi
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Wendt, Judith
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Zelenika, Diana
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Zhang, Mingfeng
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Landi, Maria Ter ...
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Thorleifsson, Gu ...
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Bishop, D. Timot ...
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Amos, Christophe ...
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Hayward, Nichola ...
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Stefansson, Kari
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Bishop, Julia A. ...
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Barrett, Jennife ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Surgery
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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Nature Genetics
- By the university
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Lund University
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Karolinska Institutet