Sökning: onr:"swepub:oai:lup.lub.lu.se:fe2f4a6a-1e02-4741-a890-89d9989a98c1" >
Antidiabetic Action...
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Alonso-Magdalena, Paloma
(författare)
Antidiabetic Actions of an Estrogen Receptor beta Selective Agonist
- Artikel/kapitelEngelska2013
Förlag, utgivningsår, omfång ...
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2013-05-17
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American Diabetes Association,2013
Nummerbeteckningar
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LIBRIS-ID:oai:lup.lub.lu.se:fe2f4a6a-1e02-4741-a890-89d9989a98c1
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https://lup.lub.lu.se/record/3927066URI
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https://doi.org/10.2337/db12-1562DOI
Kompletterande språkuppgifter
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Språk:engelska
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Sammanfattning på:engelska
Ingår i deldatabas
Klassifikation
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Ämneskategori:art swepub-publicationtype
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Ämneskategori:ref swepub-contenttype
Anmärkningar
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The estrogen receptor beta (ER beta) is emerging as an important player in the physiology of the endocrine pancreas. We evaluated the role and antidiabetic actions of the ER beta selective agonist WAY200070 as an insulinotropic molecule. We demonstrate that WAY200070 enhances glucose-stimulated insulin secretion both in mouse and human islets. In vivo experiments showed that a single administration of WAY200070 leads to an increase in plasma insulin levels with a concomitant improved response to a glucose load. Two-week treatment administration increased glucose-induced insulin release and pancreatic beta-cell mass and improved glucose and insulin sensitivity. In addition, streptozotocin-nicotinamide-induced diabetic mice treated with WAY200070 exhibited a significant improvement in plasma insulin levels and glucose tolerance as well as a regeneration of pancreatic beta-cell mass. Studies performed in db/db mice demonstrated that this compound restored first-phase insulin secretion and enhanced pancreatic beta-cell mass. We conclude that ER beta agonists should be considered as new targets for the treatment of diabetes.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Ropero, Ana B.
(författare)
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Garcia-Arevalo, Marta
(författare)
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Soriano, Sergi
(författare)
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Quesada, Ivan
(författare)
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Jabar Muhammed, SarheedLund University,Lunds universitet,Islet cell physiology,Forskargrupper vid Lunds universitet,Lund University Research Groups(Swepub:lu)med-sjb
(författare)
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Salehi, S AlbertLund University,Lunds universitet,Islet cell physiology,Forskargrupper vid Lunds universitet,Lund University Research Groups(Swepub:lu)farm-sal
(författare)
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Gustafsson, Jan-Ake
(författare)
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Nadal, Angel
(författare)
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Islet cell physiologyForskargrupper vid Lunds universitet
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Diabetes: American Diabetes Association62:6, s. 2015-20251939-327X0012-1797
Internetlänk
Hitta via bibliotek
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Diabetes
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