(WFRF:(Schmidt Christensen Anja))
Search: (WFRF:(Schmidt Christensen Anja)) > The immunomodulator...
- 8 of 17
- Previous record
- Next record
- To hitlist
The immunomodulatory quinoline-3-carboxamide paquinimod reverses established fibrosis in a novel mouse model for liver fibrosis
-
- Fransén Pettersson, Nina (author)
- Lund University,Lunds universitet,Autoimmunitet,Forskargrupper vid Lunds universitet,Autoimmunity,Lund University Research Groups
-
- Deronic, Adnan (author)
- Lund University,Lunds universitet,Immunologi,Forskargrupper vid Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Immunology,Lund University Research Groups,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine
-
- Nilsson, Julia (author)
- Lund University,Lunds universitet,Autoimmunitet,Forskargrupper vid Lunds universitet,Autoimmunity,Lund University Research Groups
- show more...
- show less...
- (creator_code:org_t)
- 2018-09-05
- 2018
- English.
- In: PLoS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 13:9
- Journal article (peer-reviewed)
Abstract
Subject headings
Close
- Quinoline-3-carboxamides (Q substances) are small molecule compounds with anti-inflammatory properties. In this study, we used one of these substances, Paquinimod, to treat a novel model for chronic liver inflammation and liver fibrosis, the NOD-Inflammation Fibrosis (N-IF) mouse. We show that treatment of N-IF mice significantly reduced inflammation and resulted in the regression of fibrosis, even when the treatment was initiated after onset of disease. The reduced disease phenotype was associated with a systemic decrease in the number and reduced activation of disease-promoting transgenic natural killer T (NKT)-II cells and their type 2-cytokine expression profile. Paquinimod treatment also led to a reduction of CD115+ Ly6Chi monocytes and CD11b+ F4/80+ CD206+ macrophages.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
- 8 of 17
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Fransén Petterss ...
- Deronic, Adnan
- Nilsson, Julia
- Hannibal, Tine
- Hansen, Lisbeth
- Schmidt-Christen ...
- show more...
- Ivars, Fredrik
- Holmberg, Dan
- show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Basic Medicine
- and Immunology in th ...
- Articles in the publication
- PLoS ONE
- By the university
- Lund University
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
