Search: WFRF:(Bright Chloe J.)
> (2018) >
Risk of Soft-Tissue...
Risk of Soft-Tissue Sarcoma Among 69 460 Five-Year Survivors of Childhood Cancer in Europe
-
- Bright, Chloe J (author)
- University of Birmingham
-
- Hawkins, Mike M (author)
- University of Birmingham
-
- Winter, David L (author)
- University of Birmingham
-
show more...
-
- Alessi, Daniela (author)
- University of Turin
-
Allodji, Rodrigue S (author)
-
Bagnasco, Francesca (author)
-
Bárdi, Edit (author)
-
Bautz, Andrea (author)
-
Byrne, Julianne (author)
-
Feijen, Elizabeth A M (author)
-
Fidler, Miranda M (author)
-
- Garwicz, Stanislaw (author)
- Lund University,Lunds universitet,Sena effekter efter barncancerbehandling,Forskargrupper vid Lunds universitet,Late effects after childhood cancer treatment,Lund University Research Groups,Skåne University Hospital
-
Grabow, Desiree (author)
-
Gudmundsdottir, Thorgerdur (author)
-
Guha, Joyeeta (author)
-
Haddy, Nadia (author)
-
Jankovic, Momcilo (author)
-
Kaatsch, Peter (author)
-
Kaiser, Melanie (author)
-
Kuehni, Claudia E (author)
-
- Linge, Helena (author)
- Lund University,Lunds universitet,Sena effekter efter barncancerbehandling,Forskargrupper vid Lunds universitet,SEBRA Sepsis and Bacterial Resistance Alliance,Masspektrometri,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,BioMS,Late effects after childhood cancer treatment,Lund University Research Groups,Mass Spectrometry,Section V,Department of Clinical Sciences, Lund,Faculty of Medicine
-
Øfstaas, Hilde (author)
-
Ronckers, Cecile M (author)
-
Skinner, Roderick (author)
-
Teepen, Jop C (author)
-
Terenziani, Monica (author)
-
Vu-Bezin, Giao (author)
-
Wesenberg, Finn (author)
-
- Wiebe, Thomas (author)
- Lund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Sena effekter efter barncancerbehandling,Forskargrupper vid Lunds universitet,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Late effects after childhood cancer treatment,Lund University Research Groups,Skåne University Hospital
-
Sacerdote, Carlotta (author)
-
Jakab, Zsuzsanna (author)
-
Haupt, Riccardo (author)
-
Lähteenmäki, Päivi (author)
-
- Zaletel, Lorna Zadravec (author)
- Institute of Oncology, Ljubljana
-
- Kuonen, Rahel (author)
- Swiss Childhood Cancer Registry
-
- Winther, Jeanette F (author)
- Danish Cancer Society
-
- de Vathaire, Florent (author)
- Centre for Research in Epidemiology and Population Health (CESP)
-
- Kremer, Leontien C (author)
- Princess Maxima Center for Pediatric Oncology/Hematology
-
- Hjorth, Lars (author)
- Lund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Sena effekter efter barncancerbehandling,Forskargrupper vid Lunds universitet,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Late effects after childhood cancer treatment,Lund University Research Groups,Skåne University Hospital
-
- Reulen, Raoul C (author)
- University of Birmingham
-
show less...
-
(creator_code:org_t)
-
- 2017-11-20
- 2018
- English 12 s.
-
In: Journal of the National Cancer Institute. - : Oxford University Press (OUP). - 1460-2105 .- 0027-8874. ; 110:6
- Related links:
-
http://dx.doi.org/10... (free)
-
show more...
-
https://academic.oup...
-
https://lup.lub.lu.s...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- Background: Childhood cancer survivors are at risk of subsequent primary soft-tissue sarcomas (STS), but the risks of specific STS histological subtypes are unknown. We quantified the risk of STS histological subtypes after specific types of childhood cancer.Methods: We pooled data from 13 European cohorts, yielding a cohort of 69 460 five-year survivors of childhood cancer. Standardized incidence ratios (SIRs) and absolute excess risks (AERs) were calculated.Results: Overall, 301 STS developed compared with 19 expected (SIR = 15.7, 95% confidence interval [CI] = 14.0 to 17.6). The highest standardized incidence ratios were for malignant peripheral nerve sheath tumors (MPNST; SIR = 40.6, 95% CI = 29.6 to 54.3), leiomyosarcomas (SIR = 29.9, 95% CI = 23.7 to 37.2), and fibromatous neoplasms (SIR = 12.3, 95% CI = 9.3 to 16.0). SIRs for MPNST were highest following central nervous system tumors (SIR = 80.5, 95% CI = 48.4 to 125.7), Hodgkin lymphoma (SIR = 81.3, 95% CI = 35.1 to 160.1), and Wilms tumor (SIR = 76.0, 95% CI = 27.9 to 165.4). Standardized incidence ratios for leiomyosarcoma were highest following retinoblastoma (SIR = 342.9, 95% CI = 245.0 to 466.9) and Wilms tumor (SIR = 74.2, 95% CI = 37.1 to 132.8). AERs for all STS subtypes were generally low at all years from diagnosis (AER < 1 per 10 000 person-years), except for leiomyosarcoma following retinoblastoma, for which the AER reached 52.7 (95% CI = 20.0 to 85.5) per 10 000 person-years among patients who had survived at least 45 years from diagnosis of retinoblastoma.Conclusions: For the first time, we provide risk estimates of specific STS subtypes following childhood cancers and give evidence that risks of MPNSTs, leiomyosarcomas, and fibromatous neoplasms are particularly increased. While the multiplicative excess risks relative to the general population are substantial, the absolute excess risk of developing any STS subtype is low, except for leiomyosarcoma after retinoblastoma. These results are likely to be informative for both survivors and health care providers.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
Find in a library
To the university's database
- By the author/editor
-
Bright, Chloe J
-
Hawkins, Mike M
-
Winter, David L
-
Alessi, Daniela
-
Allodji, Rodrigu ...
-
Bagnasco, France ...
-
show more...
-
Bárdi, Edit
-
Bautz, Andrea
-
Byrne, Julianne
-
Feijen, Elizabet ...
-
Fidler, Miranda ...
-
Garwicz, Stanisl ...
-
Grabow, Desiree
-
Gudmundsdottir, ...
-
Guha, Joyeeta
-
Haddy, Nadia
-
Jankovic, Momcil ...
-
Kaatsch, Peter
-
Kaiser, Melanie
-
Kuehni, Claudia ...
-
Linge, Helena
-
Øfstaas, Hilde
-
Ronckers, Cecile ...
-
Skinner, Roderic ...
-
Teepen, Jop C
-
Terenziani, Moni ...
-
Vu-Bezin, Giao
-
Wesenberg, Finn
-
Wiebe, Thomas
-
Sacerdote, Carlo ...
-
Jakab, Zsuzsanna
-
Haupt, Riccardo
-
Lähteenmäki, Päi ...
-
Zaletel, Lorna Z ...
-
Kuonen, Rahel
-
Winther, Jeanett ...
-
de Vathaire, Flo ...
-
Kremer, Leontien ...
-
Hjorth, Lars
-
Reulen, Raoul C
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Cancer and Oncol ...
- Articles in the publication
-
Journal of the N ...
- By the university
-
Lund University