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WFRF:(Ronckers Cecile M.)
 

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  • Bright, Chloe JUniversity of Birmingham (author)

Risk of Soft-Tissue Sarcoma Among 69 460 Five-Year Survivors of Childhood Cancer in Europe

  • Article/chapterEnglish2018

Publisher, publication year, extent ...

  • 2017-11-20
  • Oxford University Press (OUP),2018
  • 12 s.

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:ffaaca2a-fb8a-4e3e-b9d9-1f7fd6ca922a
  • https://lup.lub.lu.se/record/ffaaca2a-fb8a-4e3e-b9d9-1f7fd6ca922aURI
  • https://doi.org/10.1093/jnci/djx235DOI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Background: Childhood cancer survivors are at risk of subsequent primary soft-tissue sarcomas (STS), but the risks of specific STS histological subtypes are unknown. We quantified the risk of STS histological subtypes after specific types of childhood cancer.Methods: We pooled data from 13 European cohorts, yielding a cohort of 69 460 five-year survivors of childhood cancer. Standardized incidence ratios (SIRs) and absolute excess risks (AERs) were calculated.Results: Overall, 301 STS developed compared with 19 expected (SIR = 15.7, 95% confidence interval [CI] = 14.0 to 17.6). The highest standardized incidence ratios were for malignant peripheral nerve sheath tumors (MPNST; SIR = 40.6, 95% CI = 29.6 to 54.3), leiomyosarcomas (SIR = 29.9, 95% CI = 23.7 to 37.2), and fibromatous neoplasms (SIR = 12.3, 95% CI = 9.3 to 16.0). SIRs for MPNST were highest following central nervous system tumors (SIR = 80.5, 95% CI = 48.4 to 125.7), Hodgkin lymphoma (SIR = 81.3, 95% CI = 35.1 to 160.1), and Wilms tumor (SIR = 76.0, 95% CI = 27.9 to 165.4). Standardized incidence ratios for leiomyosarcoma were highest following retinoblastoma (SIR = 342.9, 95% CI = 245.0 to 466.9) and Wilms tumor (SIR = 74.2, 95% CI = 37.1 to 132.8). AERs for all STS subtypes were generally low at all years from diagnosis (AER < 1 per 10 000 person-years), except for leiomyosarcoma following retinoblastoma, for which the AER reached 52.7 (95% CI = 20.0 to 85.5) per 10 000 person-years among patients who had survived at least 45 years from diagnosis of retinoblastoma.Conclusions: For the first time, we provide risk estimates of specific STS subtypes following childhood cancers and give evidence that risks of MPNSTs, leiomyosarcomas, and fibromatous neoplasms are particularly increased. While the multiplicative excess risks relative to the general population are substantial, the absolute excess risk of developing any STS subtype is low, except for leiomyosarcoma after retinoblastoma. These results are likely to be informative for both survivors and health care providers.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Hawkins, Mike MUniversity of Birmingham (author)
  • Winter, David LUniversity of Birmingham (author)
  • Alessi, DanielaUniversity of Turin (author)
  • Allodji, Rodrigue S (author)
  • Bagnasco, Francesca (author)
  • Bárdi, Edit (author)
  • Bautz, Andrea (author)
  • Byrne, Julianne (author)
  • Feijen, Elizabeth A M (author)
  • Fidler, Miranda M (author)
  • Garwicz, StanislawLund University,Lunds universitet,Sena effekter efter barncancerbehandling,Forskargrupper vid Lunds universitet,Late effects after childhood cancer treatment,Lund University Research Groups,Skåne University Hospital(Swepub:lu)st6750ga (author)
  • Grabow, Desiree (author)
  • Gudmundsdottir, Thorgerdur (author)
  • Guha, Joyeeta (author)
  • Haddy, Nadia (author)
  • Jankovic, Momcilo (author)
  • Kaatsch, Peter (author)
  • Kaiser, Melanie (author)
  • Kuehni, Claudia E (author)
  • Linge, HelenaLund University,Lunds universitet,Sena effekter efter barncancerbehandling,Forskargrupper vid Lunds universitet,SEBRA Sepsis and Bacterial Resistance Alliance,Masspektrometri,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,BioMS,Late effects after childhood cancer treatment,Lund University Research Groups,Mass Spectrometry,Section V,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)medk-hjo (author)
  • Øfstaas, Hilde (author)
  • Ronckers, Cecile M (author)
  • Skinner, Roderick (author)
  • Teepen, Jop C (author)
  • Terenziani, Monica (author)
  • Vu-Bezin, Giao (author)
  • Wesenberg, Finn (author)
  • Wiebe, ThomasLund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Sena effekter efter barncancerbehandling,Forskargrupper vid Lunds universitet,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Late effects after childhood cancer treatment,Lund University Research Groups,Skåne University Hospital(Swepub:lu)pedi-twi (author)
  • Sacerdote, Carlotta (author)
  • Jakab, Zsuzsanna (author)
  • Haupt, Riccardo (author)
  • Lähteenmäki, Päivi (author)
  • Zaletel, Lorna ZadravecInstitute of Oncology, Ljubljana (author)
  • Kuonen, RahelSwiss Childhood Cancer Registry (author)
  • Winther, Jeanette FDanish Cancer Society (author)
  • de Vathaire, FlorentCentre for Research in Epidemiology and Population Health (CESP) (author)
  • Kremer, Leontien CPrincess Maxima Center for Pediatric Oncology/Hematology (author)
  • Hjorth, LarsLund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Sena effekter efter barncancerbehandling,Forskargrupper vid Lunds universitet,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Late effects after childhood cancer treatment,Lund University Research Groups,Skåne University Hospital(Swepub:lu)pedi-lhj (author)
  • Reulen, Raoul CUniversity of Birmingham (author)
  • University of BirminghamUniversity of Turin (creator_code:org_t)
  • PanCareSurFup Consortium

Related titles

  • In:Journal of the National Cancer Institute: Oxford University Press (OUP)110:61460-21050027-8874

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