SwePub
Sök i LIBRIS databas

  Extended search

WFRF:(Strandqvist Anna)
 

Search: WFRF:(Strandqvist Anna) > Suboptimal psychoso...

  • Strandqvist, AnnaKarolinska Institutet (author)

Suboptimal psychosocial outcomes in patients with congenital adrenal hyperplasia : epidemiological studies in a nonbiased national cohort in Sweden

  • Article/chapterEnglish2014

Publisher, publication year, extent ...

  • Stockholm :Karolinska Institutet, Dept of Medical Epidemiology and Biostatistics,2014
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:openarchive.ki.se:10616/42086
  • ISSN:0021-972X
  • 10616/42086hdl
  • http://hdl.handle.net/10616/42086URI
  • https://doi.org/10.1210/jc.2013-3326DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:129808050URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Context: Congenital adrenal hyperplasia (CAH), CYP21A2 deficiency, results in cortisol and aldosterone deficiency and increased production of androgens, with a good genotype phenotype correlation. Objective: To study psychosocial outcomes in relation to clinical severity, CYP21A2 genotype, in men and women. Design: An epidemiological study with a matched cohort control design. Setting: All known CAH patients in Sweden. Participants: 588 patients, >95% with known severity of CAH; 100 controls per patient matched for sex, year and place of birth. Main outcome and measures: Proxies for quality of life were selected: level of education, employment, income, sick-leave, disability pension, marriage and children. Results: Women with salt-wasting (SW) CAH had completed primary education less often (OR 0.3), not explained by neonatal salt-crisis or hypoglycemia since the men did not differ from controls. Men and women in the less severe I172N genotype group were more likely to have an academic education (OR 1.8) SW women were more likely to have an income in the top 20 percentile (OR 2.0 ). Both men and women had more disability pension (OR 1.5) and sick leave (OR 1.7). The men more often had long lasting employment (OR 3.1). Men were more often (OR 1.6) while women were less often married (OR 0.7). Patients had children less often (OR 0.3). Conclusions: This study shows important outcome differences regarding education, employment, marriage and fertility depending on sex and severity of CAH. The mechanisms behind this and the increased risk for sick leave or disability pension in both men and women should be identified to improve medical and psychological care.

Added entries (persons, corporate bodies, meetings, titles ...)

  • Falhammar, HenrikKarolinska Institutet (author)
  • Lichtenstein, PaulKarolinska Institutet (author)
  • Hirschberg, Angelica LKarolinska Institutet (author)
  • Wedell, AnnaKarolinska Institutet (author)
  • Norrby, Christina (author)
  • Nordenskjöld, AgnetaKarolinska Institutet (author)
  • Frisén, LouiseKarolinska Institutet (author)
  • Nordenström, AnnaKarolinska Institutet (author)
  • Karolinska Institutet
  • Karolinska Institutet
  • Karolinska Institutet (creator_code:org_t)

Related titles

  • In:The Journal of Clinical Endocrinology & MetabolismStockholm : Karolinska Institutet, Dept of Medical Epidemiology and Biostatistics0021-972X1945-7197

Internet link

Find in a library

To the university's database

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view