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Sökning: L773:0021 9630 OR L773:1469 7610 > Tidskriftsartikel > Hypospadias and inc...

  • Butwicka, AgnieszkaKarolinska Institutet (författare)

Hypospadias and increased risk for neurodevelopmental disorders

  • Artikel/kapitelEngelska2014

Förlag, utgivningsår, omfång ...

  • 2014-07-22
  • Stockholm :Karolinska Institutet, Dept of Medical Epidemiology and Biostatistics,2014
  • electronicrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:openarchive.ki.se:10616/42126
  • ISSN:0021-9630
  • 10616/42126hdl
  • http://hdl.handle.net/10616/42126URI
  • https://doi.org/10.1111/jcpp.12290DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:130621016URI
  • https://gup.ub.gu.se/publication/209335URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • BACKGROUND: Hypospadias (aberrant opening of the urethra on the underside of the penis) occurs in 1 per 300 newborn boys. It has been previously unknown whether this common malformation is associated with increased psychiatric morbidity later in life. Studies of individuals with hypospadias also provide an opportunity to examine whether difference in androgen signaling is related to neurodevelopmental disorders. To elucidate the mechanisms behind a possible association, we also studied psychiatric outcomes among brothers of the hypospadias patients. METHODS: Registry study within a national cohort of all 9,262 males with hypospadias and their 4,936 healthy brothers born in Sweden between 1973 and 2009. Patients with hypospadias and their brothers were matched with controls by year of birth and county. The following outcomes were evaluated (1) any psychiatric (2) psychotic, (3) mood, (4) anxiety, (5) eating, and (6) personality disorders, (7) substance misuse, (8) attention-deficit hyperactivity disorder (ADHD), (9) autism spectrum disorders (ASD), (10) intellectual disability, and (11) other behavioral/emotional disorders with onset in childhood. RESULTS: Patients with hypospadias were more likely to be diagnosed with intellectual disability (OR 3.2; 95% CI 2.8-3.8), ASD (1.4; 1.2-1.7), ADHD (1.5; 1.3-1.9), and behavioral/emotional disorders (1.4; 1.2-1.6) compared with the controls. Brothers of patients with hypospadias had an increased risk of ASD (1.6; 1.3-2.1) and other behavioral/emotional disorders with onset in childhood (1.2; 0.9-1.5) in comparison to siblings of healthy individuals. A slightly higher, although not statistically significant, risk was found for intellectual disability (1.3; 1.0-1.9). No relation between other psychiatric diagnosis and hypospadias was found. CONCLUSIONS: This is the first study to identify an increased risk for neurodevelopmental disorders in patients with hypospadias, as well as an increased risk for ASD in their brothers, suggesting a common familial (genetic and/or environmental) liability.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Lichtenstein, PaulKarolinska Institutet (författare)
  • Landén, Mikael,1966Gothenburg University,Göteborgs universitet,Karolinska Institutet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xlandt (författare)
  • Nordenvall, Anna SkarinKarolinska Institutet (författare)
  • Nordenström, AnnaKarolinska Institutet (författare)
  • Nordenskjöld, AgnetaKarolinska Institutet (författare)
  • Frisén, LouiseKarolinska Institutet (författare)
  • Karolinska InstitutetInstitutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi (creator_code:org_t)
  • Karolinska Institutet
  • Karolinska Institutet

Sammanhörande titlar

  • Ingår i:Journal of Child Psychology and PsychiatryStockholm : Karolinska Institutet, Dept of Medical Epidemiology and Biostatistics0021-96301469-7610

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