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  • Bahrami, Behdokht (author)

Folate-conjugated nanoparticles as a potent therapeutic approach in targeted cancer therapy

  • Article/chapterEnglish2015

Publisher, publication year, extent ...

  • 2015-07-05
  • Stockholm :Karolinska Institutet, Dept of Oncology-Pathology,2015
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:openarchive.ki.se:10616/44967
  • ISSN:1423-0380
  • 10616/44967hdl
  • http://hdl.handle.net/10616/44967URI
  • https://doi.org/10.1007/s13277-015-3706-6DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:131903074URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • The selective and efficient drug delivery to tumor cells can remarkably improve different cancer therapeutic approaches. There are several nanoparticles (NPs) which can act as a potent drug carrier for cancer therapy. However, the specific drug delivery to cancer cells is an important issue which should be considered before designing new NPs for in vivo application. It has been shown that cancer cells over-express folate receptor (FR) in order to improve their growth. As normal cells express a significantly lower levels of FR compared to tumor cells, it seems that folate molecules can be used as potent targeting moieties in different nanocarrier-based therapeutic approaches. Moreover, there is evidence which implies folate-conjugated NPs can selectively deliver anti-tumor drugs into cancer cells both in vitro and in vivo. In this review, we will discuss about the efficiency of different folate-conjugated NPs in cancer therapy.

Added entries (persons, corporate bodies, meetings, titles ...)

  • Mohammadnia-Afrouzi, Mousa (author)
  • Bakhshaei, Peyman (author)
  • Yazdani, Yaghoub (author)
  • Ghalamfarsa, Ghasem (author)
  • Yousefi, Mehdi (author)
  • Sadreddini, Sanam (author)
  • Jadidi-Niaragh, Farhad (author)
  • Hojjat-Farsangi, MohammadKarolinska Institutet (author)
  • Karolinska Institutet
  • Karolinska Institutet
  • Karolinska Institutet (creator_code:org_t)

Related titles

  • In:Tumor BiologyStockholm : Karolinska Institutet, Dept of Oncology-Pathology1423-03801010-4283

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