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- Brand, Judith S (author)
Time-dependent risk and predictors of venous thromboembolism in breast cancer patients: a population-based cohort study
- Article/chapterEnglish2016
Publisher, publication year, extent ...
- 2016-10-11
- Stockholm :Karolinska Institutet, Dept of Medical Epidemiology and Biostatistics,2016
- electronicrdacarrier
Numbers
- LIBRIS-ID:oai:openarchive.ki.se:10616/45411
- ISSN:0008-543X
- 10616/45411hdl
- http://hdl.handle.net/10616/45411URI
- https://doi.org/10.1002/cncr.30364DOI
- http://kipublications.ki.se/Default.aspx?queryparsed=id:135303888URI
Supplementary language notes
- Language:English
- Summary in:English
Part of subdatabase
- SwePubSwePub
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Notes
- BACKGROUND: Venous thromboembolism (VTE) is a serious complication of cancer and its treatment. The current study assessed the risk and clinical predictors of VTE in breast cancer patients by time since diagnosis. METHODS: This Swedish population-based study included 8338 breast cancer patients diagnosed from 2001 to 2008 in the Stockholm-Gotland region with complete follow-up until 2012. Their incidence of VTE was compared with the incidence among 39,013 age-matched reference individuals from the general population. Cox and flexible parametric models were used to examine associations with patient, tumor, and treatment characteristics, accounting for time-dependent effects. RESULTS: Over a median follow-up of 7.2 years, 426 breast cancer patients experienced a VTE event (cumulative incidence, 5.1%). The VTE incidence was 3-fold increased (hazard ratio [HR], 3.28; 95% confidence interval [CI], 2.87-3.74) in comparison with the incidence in the general population and was highest 6 months after diagnosis (HR, 8.62; 95% CI, 6.56-11.33) with a sustained increase in risk thereafter (HR at 5 years, 2.19; 95% CI, 1.80-2.67). Independent predictors of VTE included the following: older age, being overweight, preexisting VTE, comorbid disease, tumor size > 40 mm, progesterone receptor (PR)-negative status, more than 4 affected lymph nodes, and receipt of chemo- and endocrine therapy. The impact of chemotherapy was limited to early-onset VTE, whereas comorbid disease and PR-negative status were more strongly associated with late-onset events. CONCLUSIONS: This study confirms the long-term risk of VTE in breast cancer patients and identifies a comprehensive set of clinical risk predictors. Temporal associations with patient, tumor, and treatment characteristics provide insight into the time-dependent etiology of VTE.
Added entries (persons, corporate bodies, meetings, titles ...)
- Hedayati, ElhamKarolinska Institutet (author)
- Bhoo-Pathy, Nirmala (author)
- Bergh, JonasKarolinska Institutet (author)
- Hall, PerKarolinska Institutet (author)
- Humphreys, KeithKarolinska Institutet (author)
- Ludvigsson, Jonas FKarolinska Institutet (author)
- Czene, KamilaKarolinska Institutet (author)
- Karolinska Institutet
- Karolinska Institutet
- Karolinska Institutet (creator_code:org_t)
Related titles
- In:CancerStockholm : Karolinska Institutet, Dept of Medical Epidemiology and Biostatistics0008-543X1097-0142
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