Differences in survival for patients with familial and sporadic cancer

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Lee, Myeongjee (författare)

Differences in survival for patients with familial and sporadic cancer

Artikel/kapitelEngelska2016

Förlag, utgivningsår, omfång ...

2016-11-03
Stockholm :Karolinska Institutet, Dept of Medical Epidemiology and Biostatistics,2016
electronicrdacarrier

Nummerbeteckningar

LIBRIS-ID:oai:openarchive.ki.se:10616/45418
ISSN:0020-7136
10616/45418hdl
http://hdl.handle.net/10616/45418URI
https://doi.org/10.1002/ijc.30476DOI
http://kipublications.ki.se/Default.aspx?queryparsed=id:134926469URI

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Språk:engelska
Sammanfattning på:engelska

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Family history of cancer is a well-known risk factor but the role of family history in survival is less clear. The aim of this study was to investigate the association between family history and cancer survival for the common cancers in Sweden. Using the Swedish population-based registers, patients diagnosed with the most common cancers were followed for cancer-specific death during 1991-2010. We used multivariate proportional hazards (Cox) regression models to contrast the survival of patients with a family history of cancer (individuals whose parent or sibling had a concordant cancer) to the survival of patients without a family history. Family history of cancer had a modest protective effect on survival for breast cancer (hazard ratio (HR) = 0.88, 95% confidence interval (95% CI) = 0.81 to 0.96) and prostate cancer (HR = 0.82, 95% CI = 0.75 to 0.90). In contrast, family history of cancer was associated with worse survival for nervous system cancers (HR = 1.24, 95% CI = 1.05 to 1.47) and ovarian cancer (HR = 1.20, 95% CI = 1.01 to 1.43). Furthermore, the poorer survival for ovarian cancer was consistent with a higher FIGO stage and a greater proportion of more aggressive tumors of the serous type. The better survival for patients with a family history of breast and prostate cancer may be due to medical surveillance of family members. The poor survival for ovarian cancer patients with an affected mother or sister is multifactorial, suggesting that these cancers are more aggressive than their sporadic counterparts.

Biuppslag (personer, institutioner, konferenser, titlar ...)

Reilly, MarieKarolinska Institutet (författare)
Lindström, Linda SofieKarolinska Institutet (författare)
Czene, KamilaKarolinska Institutet (författare)
Karolinska Institutet
Karolinska Institutet
Karolinska Institutet (creator_code:org_t)

Sammanhörande titlar

Ingår i:International Journal of CancerStockholm : Karolinska Institutet, Dept of Medical Epidemiology and Biostatistics0020-71361097-0215

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Av författaren/redakt...: Lee, Myeongjee; Reilly, Marie; Lindström, Linda ...; Czene, Kamila

Artiklar i publikationen: International Jo ...

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