WFRF:(Pelechano Vicent)
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- Pelechano, VicentKarolinska Institutet (author)
From transcriptional complexity to cellular phenotypes : lessons from yeast
- Article/chapterEnglish2017
Publisher, publication year, extent ...
- 2017-10-11
- Stockholm :Karolinska Institutet, Dept of Microbiology, Tumor and Cell Biology,2017
- electronicrdacarrier
Numbers
- LIBRIS-ID:oai:openarchive.ki.se:10616/46106
- ISSN:0749-503X
- 10616/46106hdl
- http://hdl.handle.net/10616/46106URI
- https://doi.org/10.1002/yea.3277DOI
- http://kipublications.ki.se/Default.aspx?queryparsed=id:137196542URI
Supplementary language notes
- Language:English
- Summary in:English
Part of subdatabase
- SwePubSwePub
Classification
Notes
- Pervasive transcription has been reported in many eukaryotic organisms, revealing a highly interleaved transcriptome organization that involves thousands of coding and non-coding RNAs. However, to date, the biological impact of transcriptome complexity is still poorly understood. Here I will review how subtle variations of the transcriptome can lead to divergent cellular phenotypes by fine-tuning both its coding potential and regulation. I will discuss strategies that can be used to link molecular variations with divergent biological outcomes. Finally, I will explore the implication of transcriptional complexity for our understanding of gene expression in the context of cell-to-cell phenotypic variability.
Subject headings and genre
- NATURVETENSKAP Biologi Bioinformatik och systembiologi hsv//swe
- NATURAL SCIENCES Biological Sciences Bioinformatics and Systems Biology hsv//eng
- MEDICIN OCH HÄLSOVETENSKAP Medicinsk bioteknologi Medicinsk bioteknologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Medical Biotechnology Medical Biotechnology hsv//eng
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- Karolinska Institutet
- Karolinska Institutet
- Karolinska Institutet (creator_code:org_t)
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- In:YeastStockholm : Karolinska Institutet, Dept of Microbiology, Tumor and Cell Biology0749-503X1097-0061
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