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Neoadjuvant therapy...
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Kauppila, Joonas HKarolinska Institutet
(author)
Neoadjuvant therapy in relation to lymphadenectomy and resection margins during surgery for oesophageal cancer
- Article/chapterEnglish2018
Publisher, publication year, extent ...
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2018-01-11
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Stockholm :Karolinska Institutet, Dept of Molecular Medicine and Surgery,2018
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electronicrdacarrier
Numbers
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LIBRIS-ID:oai:openarchive.ki.se:10616/46193
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ISSN:2045-2322
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10616/46193hdl
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http://hdl.handle.net/10616/46193URI
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https://doi.org/10.1038/s41598-017-18879-6DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:137445650URI
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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It is unclear whether gastrectomy or oesophagectomy offer better outcomes for gastro-oesophageal junction (GOJ) cancer. A total of 240 patients undergoing total gastrectomy (n = 85) or oesophagectomy (n = 155) for Siewert II-III GOJ adenocarcinoma were identified from a Swedish prospective population-based nationwide cohort. The surgical approaches were compared in relation to non-radical resection margins (main outcome) using multivariable logistic regression, providing odds ratios (ORs) and 95% confidence intervals (CIs), mean number of removed lymph nodes with standard deviation (SD) using ANCOVA, assessing mean differences and 95% CIs, and 5-year mortality using Cox regression estimating hazard ratios (HRs) and 95% CIs. The models were adjusted for age, sex, comorbidity, tumour stage, and surgeon volume. The non-radical resection rate was 15% for gastrectomy and 14% for oesophagectomy, and the adjusted OR was 1.61 (95% CI 0.68-3.83). The mean number of lymph nodes removed was 14.2 (SD +/- 9.6) for gastrectomy and 14.2 (SD +/- 10.4) for oesophagectomy, with adjusted mean difference of 2.4 (95% CI-0.2-5.0). The 5-year mortality was 76% following gastrectomy and 75% following oesophagectomy, with adjusted HR = 1.07 (95% CI 0.78-1.47). Gastrectomy and oesophagectomy for Siewert II or III GOJ cancer seem comparable regarding tumour-free resection margins, lymph nodes removal, and 5-year survival.
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Wahlin, KarlKarolinska Institutet
(author)
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Lagergren, PernillaKarolinska Institutet
(author)
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Lagergren, JesperKarolinska Institutet
(author)
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Karolinska Institutet
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Karolinska Institutet
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Karolinska Institutet
(creator_code:org_t)
Related titles
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In:Scientific ReportsStockholm : Karolinska Institutet, Dept of Molecular Medicine and Surgery2045-2322
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