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Integration of gene...
Integration of gene expression and DNA methylation identifies epigenetically controlled modules related to PM2.5 exposure
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- Merid, Simon Kebede (author)
- Karolinska Institutet
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Bustamante, Mariona (author)
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Standl, Marie (author)
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Sunyer, Jordi (author)
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Heinrich, Joachim (author)
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Lemonnier, Nathanaël (author)
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Aguilar, Daniel (author)
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Antó, Josep Maria (author)
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Bousquet, Jean (author)
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Santa-Marina, Loreto (author)
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Lertxundi, Aitana (author)
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- Bergström, Anna (author)
- Karolinska Institutet
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- Kull, Inger (author)
- Karolinska Institutet
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- Wheelock, Åsa M (author)
- Karolinska Institutet
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Koppelman, Gerard H (author)
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- Melén, Erik (author)
- Karolinska Institutet
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- Gruzieva, Olena (author)
- Karolinska Institutet
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- ISSN 0160-4120
- Stockholm : Karolinska Institutet, Dept of Clinical Science and Education, Södersjukhuset, 2020
- 2020
- English.
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In: Environment International. - Stockholm : Karolinska Institutet, Dept of Clinical Science and Education, Södersjukhuset. - 0160-4120 .- 1873-6750.
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https://doi.org/10.1...
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Abstract
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- Air pollution has been associated with adverse health effects across the life-course. Although underlying mechanisms are unclear, several studies suggested pollutant-induced changes in transcriptomic profiles. In this meta-analysis of transcriptome-wide association studies of 656 children and adolescents from three European cohorts participating in the MeDALL Consortium, we found two differentially expressed transcript clusters (FDR p < 0.05) associated with exposure to particulate matter < 2.5 µm in diameter (PM2.5) at birth, one of them mapping to the MIR1296 gene. Further, by integrating gene expression with DNA methylation using Functional Epigenetic Modules algorithms, we identified 9 and 6 modules in relation to PM2.5 exposure at birth and at current address, respectively (including NR1I2, MAPK6, TAF8 and SCARA3). In conclusion, PM2.5 exposure at birth was linked to differential gene expression in children and adolescents. Importantly, we identified several significant interactome hotspots of gene modules of relevance for complex diseases in relation to PM2.5 exposure.
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- By the author/editor
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Merid, Simon Keb ...
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Bustamante, Mari ...
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Standl, Marie
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Sunyer, Jordi
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Heinrich, Joachi ...
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Lemonnier, Natha ...
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show more...
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Aguilar, Daniel
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Antó, Josep Mari ...
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Bousquet, Jean
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Santa-Marina, Lo ...
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Lertxundi, Aitan ...
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Bergström, Anna
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Kull, Inger
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Wheelock, Åsa M
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Koppelman, Gerar ...
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Melén, Erik
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Gruzieva, Olena
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show less...
- Articles in the publication
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Environment Inte ...
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Karolinska Institutet