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Keratinocyte growth...
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Seggewiss, R
(författare)
Keratinocyte growth factor augments immune reconstitution after autologous hematopoietic progenitor cell transplantation in rhesus macaques
- Artikel/kapitelEngelska2007
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American Society of Hematology,2007
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LIBRIS-ID:oai:prod.swepub.kib.ki.se:115617718
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http://kipublications.ki.se/Default.aspx?queryparsed=id:115617718URI
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https://doi.org/10.1182/blood-2006-12-065623DOI
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Språk:engelska
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Sammanfattning på:engelska
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Opportunistic infections contribute to morbidity and mortality after peripheral blood progenitor cell (PBPC) transplantation and are related to a deficient T-cell compartment. Accelerated T-cell reconstitution may therefore be clinically beneficent. Keratinocyte growth factor (KGF) has been shown to protect thymic epithelial cells in mice. Here, we evaluated immune reconstitution after autologous CD34+ PBPC transplantation in rhesus macaques conditioned with myeloablative total body irradiation in the absence or presence of single pretotal body irradiation or repeated peritransplant KGF administration. All KGF-treated animals exhibited a well-preserved thymic architecture 12 months after graft. In contrast, thymic atrophy was observed in the majority of animals in the control group. The KGF-treated animals showed higher frequencies of naive T cells in lymph nodes after transplantation compared with the control animals. The animals given repeated doses of KGF showed the highest levels of T-cell receptor excision circles (TRECs) and the lowest frequencies of Ki67+ T cells, which suggest increased thymic-dependent reconstitution in these animals. Of note, the humoral response to a T-cell–dependent neo-antigen was significantly higher in the KGF-treated animals compared with the control animals. Thus, our findings suggest that KGF may be a useful adjuvant therapy to augment T-cell reconstitution after human PBPC transplantation.
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Lore, KKarolinska Institutet
(författare)
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Guenaga, FJ
(författare)
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Pittaluga, S
(författare)
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Mattapallil, J
(författare)
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Chow, CK
(författare)
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Koup, RA
(författare)
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Camphausen, K
(författare)
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Nason, MC
(författare)
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Meier-Schellersheim, M
(författare)
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Donahue, RE
(författare)
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Blazar, BR
(författare)
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Dunbar, CE
(författare)
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Douek, DC
(författare)
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Karolinska Institutet
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Blood: American Society of Hematology110:1, s. 441-4490006-49711528-0020
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Blood
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- Av författaren/redakt...
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Seggewiss, R
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Lore, K
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Guenaga, FJ
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Pittaluga, S
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Mattapallil, J
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Chow, CK
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visa fler...
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Koup, RA
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Camphausen, K
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Nason, MC
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Meier-Schellersh ...
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Donahue, RE
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Blazar, BR
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Dunbar, CE
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Douek, DC
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visa färre...
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Blood
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Karolinska Institutet