Postnatal cadmium exposure, neurodevelopment, and blood pressure in children at 2, 5, and 7 years of age

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Cao, Yang,Associate Professor,1972-Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USA; Department of Health Statistics, Faculty of Health Services, Second Military Medical University, Shanghai, China (författare)

Postnatal cadmium exposure, neurodevelopment, and blood pressure in children at 2, 5, and 7 years of age

Artikel/kapitelEngelska2009

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National Institute of Environmental Health Science,2009
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LIBRIS-ID:oai:DiVA.org:oru-66003
https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-66003URI
https://doi.org/10.1289/ehp.0900765DOI

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Språk:engelska
Sammanfattning på:engelska

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BACKGROUND: Adverse health effects of cadmium in adults are well documented, but little is known about the neuropsychological effects of cadmium in children, and no studies of cadmium and blood pressure in children have been conducted.OBJECTIVE: We examined the potential effects of low-level cadmium exposure on intelligence quotient, neuropsychological functions, behavior, and blood pressure among children, using blood cadmium as a measure of exposure.METHODS: We used the data from a multicenter randomized clinical trial of lead-exposed children and analyzed blood cadmium concentrations using the whole blood samples collected when children were 2 years of age. We compared neuropsychological and behavioral scores at 2, 5, and 7 years of age by cadmium level and analyzed the relationship between blood cadmium levels at 2 years of age and systolic and diastolic blood pressure at 2, 5, and 7 years of age.RESULTS: The average cadmium concentration of these children was 0.21 microg/L, lower than for adults in the National Health and Nutrition Examination Survey (NHANES), but comparable to concentrations in children < 3 years of age in NHANES. Except for the California Verbal Learning Test for Children, there were no differences in test scores among children in different cadmium categories. For children with detectable pretreatment blood cadmium, after adjusting for a variety of covariates, general linear model analyses showed that at none of the three age points was the coefficient of cadmium on Mental Development Index or IQ statistically significant. Spline regression analysis suggested that behavioral problem scores at 5 and 7 years of age tended to increase with increasing blood cadmium, but the trend was not significant. We found no significant associations between blood cadmium levels and blood pressure.CONCLUSION: We found no significant associations between background blood cadmium levels at 2 years of age and neurodevelopmental end points and blood pressure at 2, 5, and 7 years of age. The neuropsychological or hypertensive effects from longer background exposures to cadmium need further study.

Ämnesord och genrebeteckningar

MEDICIN OCH HÄLSOVETENSKAP Hälsovetenskap Arbetsmedicin och miljömedicin hsv//swe
MEDICAL AND HEALTH SCIENCES Health Sciences Occupational Health and Environmental Health hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Farmakologi och toxikologi hsv//swe
MEDICAL AND HEALTH SCIENCES Basic Medicine Pharmacology and Toxicology hsv//eng
Behavior
blood pressure
cadmium
children
clinical trial
intelligence
neurodevelopment

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Chen, AiminDepartment of Preventive Medicine and Public Health, Creighton University School of Medicine, Omaha, Nebraska, USA (författare)
Radcliffe, JerilynnChildren’s Hospital of Philadelphia and University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA (författare)
Dietrich, Kim N.Department of Environmental Health, Division of Epidemiology and Biostatistics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA (författare)
Jones, Robert L.Inorganic and Radiation Analytical Toxicology Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA (författare)
Caldwell, KathleenInorganic and Radiation Analytical Toxicology Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA (författare)
Rogan, Walter J.Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USA (författare)
Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USA; Department of Health Statistics, Faculty of Health Services, Second Military Medical University, Shanghai, ChinaDepartment of Preventive Medicine and Public Health, Creighton University School of Medicine, Omaha, Nebraska, USA (creator_code:org_t)

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Ingår i:Journal of Environmental Health Perspectives: National Institute of Environmental Health Science117:10, s. 1580-15860091-67651552-9924

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