Search: id:"swepub:oai:prod.swepub.kib.ki.se:116753891" >
Autologous antitumo...
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Alici, EKarolinska Institutet
(author)
Autologous antitumor activity by NK cells expanded from myeloma patients using GMP-compliant components
- Article/chapterEnglish2008
Publisher, publication year, extent ...
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American Society of Hematology,2008
Numbers
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LIBRIS-ID:oai:prod.swepub.kib.ki.se:116753891
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http://kipublications.ki.se/Default.aspx?queryparsed=id:116753891URI
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https://doi.org/10.1182/blood-2007-09-110312DOI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Multiple myeloma (MM) is an incurable plasma cell malignancy with poor outcome. The most promising therapeutic options currently available are combinations of transplantation, targeted pharmacotherapy, and immunotherapy. Cell-based immunotherapy after hematopoietic stem-cell transplantation has been attempted, but with limited efficacy. Natural killer (NK) cells are interesting candidates for new means of immunotherapy; however, their potential clinical use in MM has not been extensively studied. Here, we explored the possibility of expanding NK cells from the peripheral blood of 7 newly diagnosed, untreated MM patients, using good manufacturing practice (GMP)–compliant components. After 20 days of culture, the number of NK cells from these patients had expanded on average 1600-fold. Moreover, expanded NK cells showed significant cytotoxicity against primary autologous MM cells, yet retained their tolerance against nonmalignant cells. Based on these findings, we propose that autologous NK cells expanded ex vivo deserve further attention as a possible new treatment modality for MM.
Added entries (persons, corporate bodies, meetings, titles ...)
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Sutlu, TKarolinska Institutet
(author)
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Bojrkstrand, B
(author)
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Gilljam, M
(author)
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Stellan, B
(author)
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Nahi, HKarolinska Institutet
(author)
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Quezada, HCKarolinska Institutet
(author)
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Gahrton, GKarolinska Institutet
(author)
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Ljunggren, HGKarolinska Institutet
(author)
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Dilber, MS
(author)
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Karolinska Institutet
(creator_code:org_t)
Related titles
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In:Blood: American Society of Hematology111:6, s. 3155-31620006-49711528-0020
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Blood
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Alici, E
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Sutlu, T
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Bojrkstrand, B
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Gilljam, M
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Stellan, B
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Nahi, H
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Quezada, HC
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Gahrton, G
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Ljunggren, HG
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Dilber, MS
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Blood
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Karolinska Institutet