Cortical serotonin 1A receptor levels are associated with depression in patients with dementia with Lewy bodies and Parkinson's disease dementia

• <i>Background:</i> Serotonin 1A receptors (5-HT_1A) have not been studied in dementia with Lewy bodies (DLB) or Parkinson’s disease dementia (PDD) patients with depression. <i>Aim:</i> To examine 5-HT_1A in DLB and PDD postmortem in relation to depression. <i>Methods:</i> [³H]8-hydroxy-2-dipropylaminotetralin binding to 5-HT_1A was determined in temporal cortex (Brodmann areas, BA20 and BA36) from 10 DLB patients, 17 PDD patients and 9 controls. <i>Results:</i> 5-HT_1A density was significantly higher in BA36 in combined DLB/PDD patients with depression, but was unaltered in BA20. <i>Conclusion: </i>Higher BA36 5-HT_1A density in PDD and DLB patients than in control is dependent on whether the patient had experienced depression during life, not DLB/PDD diagnosis. A 5-HT_1A antagonist adjuvant may improve treatment of depression in dementia.

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